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Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Polymeric nanohydrogels show potential for skin drug delivery but have concerns like toxicity and regulatory hurdles.

Cannabinoids may help treat various skin conditions.

TGFβ signaling prevents sebaceous gland cells from producing fats.

The right amount of retinoic acid is essential for normal hair growth and development.

Seaweeds contain beneficial compounds with potential uses in food, cosmetics, and health, but more research is needed to improve extraction and safety.

Nanostructured delivery systems could potentially improve hair loss treatment by targeting drugs to hair follicles, reducing side effects and dosage, but the best size, charge, and materials for these systems need further investigation.

Deep eutectic solvents are eco-friendly and effective for extracting useful pharmaceutical compounds.

Polyamidoamine dendrimers can change the strength and direction of electroosmotic flow through the skin, affecting drug delivery.

Black cumin and its nanoformulations show promise in treating neurodegenerative diseases.

Tea seed oil in nanostructured carriers stimulates hair growth and feels less greasy when applied.

K18® and Olaplex® both effectively repair bleached hair, improving its strength, smoothness, and overall health.

Bioassays help find useful compounds in nature for making medicines, supplements, and cosmetics.

Melatonin helps hair grow by activating the RORα receptor in goats.

Equisetum debile extracts may help with skin whitening, anti-wrinkle, and anti-hair loss treatments.

Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

The microemulsion delivered the dye deeper into the skin than the cream.

Ultrasound increases skin permeability but blocks hair follicles.

Greasy hair spreads sebum twice as much as nongreasy hair over time.

The model better predicts how water-loving and fat-loving substances move through the skin by including tiny pores and hair follicle paths.

Hair follicles are important for drug delivery through the skin, but better methods are needed to understand and improve this process.

Hair follicles help substances penetrate the skin faster and more effectively.

Researchers developed a method to measure drugs in hair follicles and found that both water-loving and fat-loving drugs can be detected after being applied to the skin.

Rubbing skin increases absorption of water-soluble drugs from lotions and creams, but not oil-soluble drugs.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

Ethosomes improve drug delivery through the skin but may have side effects like irritation.

Ethosomes are a promising way to deliver drugs through the skin.

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.