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Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Telocytes might help with skin repair and regeneration.

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

Skin fat helps with body temperature control and has other active roles in health.

Alopecia areata is likely caused by a combination of genetic factors and immune system dysfunction, and may represent different diseases with various causes.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

The research found genetic differences in identical twins that could explain why one twin has a disease while the other does not.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Hair follicles on the scalp interact with and respond to the nervous system, influencing their own behavior and growth.

The research suggests that Tourette syndrome is linked to both brain signaling and immune system pathways.

Female donor to male recipient sex mismatch and positive ACA-IgG are key risk factors for vitiligo and alopecia areata in chronic GvHD patients.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

The spiny mouse is a unique menstruating rodent that can help us understand menstruation and reproductive disorders.

The research identified genes and pathways important for sheep wool growth and shedding.

COVID-19 may harm male fertility and damage the reproductive system.