Resolution of Refractory Generalized Granuloma Annulare After Treatment With Alitretinoin

    April 2022 in “ JAAD case reports ”
    Jun Hyo Lee, Soyun Cho
    TLDR Alitretinoin helped clear up a skin condition called generalized granuloma annulare in an elderly man.
    A 72-year-old man with generalized granuloma annulare (GGA) unresponsive to multiple treatments achieved remission after 15 months of alitretinoin therapy. Partial remission was observed after 7 months, but switching to hydroxychloroquine led to exacerbation. Resuming alitretinoin resulted in complete flattening of lesions within 8 months. Alitretinoin, a pan-retinoid receptor agonist, demonstrated strong anti-inflammatory effects without significant side effects, suggesting its potential efficacy in treating refractory GGA, especially in elderly patients.
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