Epigenetic Age Estimation in Saliva and Buccal Cells

    August 2022 in “ Forensic Science International Genetics ”
    A. Ambroa-Conde, M. de la Puente, Ana Mosquera‐Miguel, C. Phillips, Mariela Cal, Antonio Gómez‐Tato, José Antonio Álvarez‐Dios, M. de la Puente, J. Ruiz-Ramírez, M.V. Lareu, A. Freire-Aradas
    Studysummary This study developed and validated tissue-specific and age prediction models using epigenetic markers, achieving up to 83.69% correct classification for tissue origin and a median absolute error of ±3.66 years for age estimation.
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    The study developed a model to predict age using DNA methylation markers from saliva and buccal cells, achieving a mean absolute error (MAE) of ±3.66 years. The model used seven CpG sites and was validated with 184 samples. Logistic regression achieved an 88.59% correct classification rate for tissue prediction. The study concluded that the combined model for both tissues is reliable for forensic applications, with a minimum of 10 ng of DNA required for accurate results. The final age predictor model is available online for forensic use.
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