Defective Expression of the Gap Junction Protein Pannexin-1 Channel Contributes to the Formation of PCOS-Related Androgenetic Alopecia

    January 2023 in “ Advances in reproductive sciences ”
    Sule Gencoglu, Fatma Tanilir Cagiran, Zercan Kali
    Studysummary This study found that women with PCOS and female androgenetic alopecia had significantly higher serum pannexin-1 channel levels compared to those without PCOS, suggesting a potential role in hair loss etiology.
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    Research cited in this study 9

    1. Pannexin 3 Regulates Skin Development via Epiprofin Scientific Reports · 2021
    2. Female Androgenetic Alopecia: An Update on Diagnosis and Management American Journal of Clinical Dermatology · 2019
    3. Expert Consensus on the Management of Androgenetic Alopecia in India International Journal of Trichology · 2019
    4. Genetic and Molecular Aspects of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018
    5. Dermatologic Manifestations of Endocrine Disorders Translational pediatrics · 2017
    6. Androgenetic Alopecia: A Review Endocrine · 2017
    7. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    8. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    9. The Unit Area Trichogram in the Assessment of Androgen-Dependent Alopecia British Journal of Dermatology · 1983