February 2020 in “Scholars academic journal of pharmacy” This case report describes a 78-year-old patient whose orlistat treatment for obesity likely led to hepatotoxicity, which improved after the medication was discontinued.
August 2024 in “Bioimpacts” In this study on mice, a hydro-alcoholic solution containing kopexil significantly enhanced hair growth and increased hair-promoting factors without causing notable liver or kidney toxicity compared to minoxidil.
4 citations
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October 2020 in “Therapeutic drug monitoring” In this study, researchers found that targeting a tacrolimus trough level of 4–7 ng/mL after liver transplantation resulted in comparable graft and patient survival rates to higher levels, while improving liver and kidney function markers.
January 2026 in “Food Science and Human Wellness” This research examined krill oil's effects on benign prostatic hyperplasia and found that it inhibited the growth of prostate cells in vitro and reduced prostate size and weight in a BPH rat model, suggesting potential as a prophylactic or therapeutic agent for BPH.
10 citations
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April 1965 in “Journal of Nutrition” Changing mineral levels in rats' diets can prevent kidney stones, affect hair growth, and influence weight gain.
June 2023 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ” In this study, researchers found that high doses of rosemary extract given to lactating mother rats adversely affected their offspring, causing weight issues and damage to liver, kidney, and testis tissues, suggesting potential teratogenic risks if used during human pregnancy and lactation.
May 2023 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ” In this study, young albino rats whose mothers received high doses of rosemary extract during lactation showed negative health effects, including inhibited weight gain and organ damage, suggesting potential teratogenicity of rosemary extract when used in such conditions.
17 citations
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June 2012 in “European journal of medicinal chemistry” This study found that compounds 21–23 and 25 exhibited strong 5α-reductase II inhibition in vitro and significantly reduced rat prostate weight, performing comparably to finasteride.
55 citations
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August 2012 in “Resources and Environment” This study found that landfill leachates from Olusosun and Aba-Eku in Nigeria can cause liver and kidney dysfunction in Wistar rats, potentially posing a health risk through chemical exposure.
1 citations
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January 2021 in “Acta Cirurgica Brasileira” This study found that both finasteride and dutasteride led to morphological and functional kidney damage in rats, with more severe effects observed in the dutasteride group.
July 2025 in “Journal of Research in Siddha Medicine” This study investigated the sub-acute toxicity of Eclipta alba extract in Wistar albino rats, finding generally comparable hematological and biochemical parameters to controls, but noted mild morphological liver and kidney changes at the highest dose, highlighting a key area for further safety research.
33 citations
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January 1977 in “PubMed” This study found that weanling rats fed diets with oxidized rapeseed oil or lard had increased heart lipid levels, various symptoms of fat toxicity, and organ-specific tissue damage.
97 citations
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October 2019 in “Journal of Translational Medicine” This review discusses the use of very low-calorie ketogenic diets for obesity management and provides recommendations for nutrition experts, but reports no new clinical results.
3 citations
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September 2021 in “International Journal of Molecular Sciences” This study suggests that women with polycystic ovary syndrome may have an increased risk of COVID-19-related cardiac and renal complications, and that weight loss through lifestyle changes could help reduce these risks.
18 citations
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October 2021 in “Frontiers in Physiology” This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.
December 2023 in “Journal of nutritional science and vitaminology” This study in mice found that a zinc-deficient diet suppressed body weight gain and increased kidney and cecum tissue weight without decreasing serum alkaline phosphatase activity. Additionally, zinc deficiency caused alopecia and intestinal changes in C57BL/6J mice, potentially affecting nutritional status.
May 2025 in “International Journal of Trichology” This retrospective study in a tertiary hair clinic concluded that routine monitoring of heart rate, weight, liver, and kidney function is not necessary for asymptomatic patients with normal baseline values undergoing low-dose oral minoxidil treatment, although monitoring is advised for those with preexisting renal impairment.
2 citations
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February 2016 in “African Journal of Traditional Complementary and Alternative Medicines” In this study, prolonged ingestion of linseed in rabbits was observed to be safe, showing no significant weight gain or anatomical anomalies in liver and kidney biopsies.
36 citations
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July 1987 in “Journal of toxicology and environmental health” This study found that rats fed diets with heated corn or peanut oil showed signs of toxicity, including liver and kidney weight increases, diarrhea, and ceased spermatogenesis, compared to those consuming fresh oils.
March 2026 in “Pediatrics in Review” This case report describes a 17-year-old boy with obesity who was diagnosed with severe hypothyroidism, leading to myopathy, rhabdomyolysis, acute kidney injury, and bradycardia. Following treatment with IV levothyroxine and liothyronine, his symptoms improved, and he achieved significant weight loss over five months.
August 2023 in “Gadua Journal of Pure and Allied Science” This study on diabetic rats reported that Ziziphus spina-christi ethanol leaf extract significantly reduced blood glucose levels and improved liver and kidney function, suggesting possible benefits in managing diabetes symptoms in this animal model.
17 citations
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January 2021 in “Agrobiological Records” This study reported that allethrin caused dose-dependent toxico-pathological effects, including decreased feed intake, body weight, and blood parameters, and organ damage in adult male albino rats.
13 citations
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December 2021 in “Toxics” In this study, PEGDE above 10,000 μg/mouse caused subcutaneous toxicity including ulceration in mice, but did not affect liver, spleen, or kidney tissues.
3 citations
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July 1969 in “PubMed” This study found that unilateral neutron irradiation in pigs significantly decreased the uptake of radioactive zinc in blood, impaired growth, and led to decreased organ weights and hair pigmentation changes on the irradiated side.
13 citations
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May 2014 in “PubMed” This study observed that class IV diffuse proliferative glomerulonephritis was the most common form of lupus nephritis among the children studied, with remission achieved in a significant portion after treatment.
1 citations
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July 2022 in “Case reports in endocrinology” This case report concludes that a combination of physical examination, hormonal evaluation, and imaging studies is crucial for identifying malignant adrenal masses, with radical excision and adjuvant therapy improving patient outcomes.
18 citations
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September 2011 in “Livestock science” This study found that maternal Nano-Se supplementation in cashmere goats improved antioxidant status and promoted secondary hair follicle development in fetuses at 110 days.
This study found that adding 1.5% lactic acid to mink diets during the hair growth period significantly improved production performance and maintained visceral health.
20 citations
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September 2019 in “South African Journal of Botany” This study found that Teucrium polium L. subsp. geyrii Maire extract demonstrated a large safety margin in acute and subacute toxicity tests on mice and significantly enhanced wound healing in rats, especially with callus extract, by improving cell proliferation and wound contraction.
17 citations
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January 2012 in “IOSR Journal of Environmental Science Toxicology and Food Technology” This study found that high doses of ethyl acetate extract from Tridax procumbens can have specific toxic effects in rats, including organ damage and significant changes in some serum biochemical parameters.