Effect of Zinc-Deficient Diet on Two Strains of Mice
December 2023
in “
Journal of nutritional science and vitaminology
”
TLDR A zinc-deficient diet stunted growth and affected organs in mice, with C57BL/6J mice showing more severe symptoms.
This study investigated the effects of a zinc-deficient diet on ICR and C57BL/6J mice strains, revealing that zinc deficiency suppressed body weight gain and increased kidney and cecum tissue weight in both strains. Notably, C57BL/6J mice exhibited alopecia, loss of intestinal villi, and affected intestinal mucosa, indicating potential risks for poor nutritional status. Contrary to previous reports, serum alkaline phosphatase (ALP) activity did not decrease in either strain, suggesting that ALP may not be a reliable marker for zinc deficiency in these mice.
