Anti-Hyperglycemic and Selected Organ Protective Effects of Ziziphus Spina-Christi Hydroethanol Leaf Extract in Alloxan Induced Diabetic Rats

The study investigated the effects of Ziziphus spina-christi ethanol leaf extract on diabetic rats, focusing on its potential anti-hyperglycaemic, anti-dyslipidaemic, and organ protective properties. Fifteen albino Wistar rats were divided into five groups, including a normal control, a normal group treated with 150mg/kg body weight (bwt) of the extract, a diabetic control, a diabetic group treated with the same dose of the extract, and a diabetic group treated with Metformin. After 14 days, the extract and Metformin groups showed a significant reduction in blood glucose levels and improved liver enzyme profiles compared to the diabetic control. Additionally, the extract and Metformin groups had lower creatinine and urea concentrations, indicating kidney protection, and a better lipid profile, with higher high-density lipoprotein and lower triacylglycerol levels. These results support the traditional use of Ziziphus spina-christi in diabetes management.