Allethrin Induced Toxicopathological Alterations in Adult Male Albino Rats

This study investigated the toxicopathological effects of allethrin on 60 adult male albino rats, divided into 4 groups, with groups B, C, and D receiving 0.5, 1.0, and 1.5 g/kg body weight of allethrin, respectively, for 14 days. Treated rats exhibited symptoms such as dullness, erected hairs, alopecia, reduced feed and water intake, and severe symptoms like tremors and coma, with mortality in groups C and D. Significant decreases in erythrocyte and leukocyte counts, hemoglobin concentration, and packed cell volume were observed in treated groups. Histopathological analysis showed kidney and liver damage, including necrotic tubules and vacuolar degeneration. The study concluded that allethrin caused dose and time-dependent toxicopathological effects in the rats.