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GlossaryKeratin Gene Expression

process where cells produce keratin proteins for hair and skin

Keratin gene expression refers to the process by which cells produce keratin, a type of protein that is a key structural component of hair, skin, and nails. This involves the activation of specific genes within a cell's DNA that encode for keratin proteins, leading to their synthesis and assembly. Understanding keratin gene expression is crucial for studying hair growth, skin disorders, and conditions like alopecia.

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research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter

215 citations, November 2000 in “Journal of Investigative Dermatology”

The system allows precise control of gene expression in mouse skin, useful for studying skin biology.

research The Microanatomy, Cell Replication, and Keratin Gene Expression of Hair Follicles During a Photoperiod-Induced Growth Cycle in Sheep

20 citations, January 1995 in “Cells tissues organs”

Changing light periods synchronized wool growth cycles in sheep.

DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

research DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

July 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.

research A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms

3 citations, March 2023 in “International journal of molecular sciences”

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

research DNA Dioxygenases TET Regulate Keratin Gene Expression and Enhancer Networks Within Lineage-Specific Gene Loci During Epidermal and Hair Follicle-Specific Keratinocyte Differentiation

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TET enzymes are important for skin and hair development by controlling gene activity in specific areas.

research Revisiting the Significance of Keratin Expression in Complex Epithelia

1 citations, July 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Keratin gene expression helps understand different types of skin cells and their development, and should be used carefully as biological markers.

research Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression

14 citations, April 2016 in “PloS one”

The KRTAP11-1 gene promoter is crucial for specific expression in sheep wool cortex.

research Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases?

26 citations, May 2014 in “BioEssays”

Using neurohormones to control keratin can lead to new skin disease treatments.

research Comparative Genomics of the Keratin-Associated Protein Gene Clusters in Human, Chimpanzee, and Baboon

8 citations, March 2004 in “Mammalian genome”

KAP genes are crucial for hair development and show both shared and unique traits in humans, chimpanzees, and baboons.

research Differential Gene Expression Profiles in Fetal Skin of Rex Rabbits with Different Wool Density

4 citations, September 2016 in “World Rabbit Science”

High wool density in Rex rabbits is linked to specific gene activity affecting hair follicle development.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

62 citations, January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Revisiting the Significance of Keratin Expression in Complex Epithelia

6 citations, October 2022 in “Journal of cell science”

Keratin genes change gradually during skin cell development and should be used carefully as biomarkers.

research Evaluation of Gene Expression Patterns in Micrografts Demonstrates Induction of Catagen-Like Processes During Storage

5 citations, January 2017 in “Dermatologic Surgery”

Storing hair follicle micrografts for longer times can cause them to enter a state similar to the natural hair shedding phase, which might impact hair transplant results.

research Identification of the Keratin-Associated Protein 22-2 Gene in Capra Hircus and Its Association with Cashmere Traits

1 citations, September 2023 in “Animals”

A new goat gene affects cashmere fiber thickness; certain variations can make the fibers coarser.

research Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in Mouse Skin

11 citations, January 2015 in “Skin pharmacology and physiology”

Eating collagen peptides may help with skin and hair growth.

research The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family

14 citations, December 2016 in “PloS one”

Keratin 26 affects cashmere goat hair growth and is influenced by various treatments.

research Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

January 2023 in “Kafkas üniversitesi veteriner fakültesi dergisi/Kafkas üniversitesi veteriner fakültesi dergisi”

Seasonal changes affect gene activity linked to hair growth in Angora goats.

research Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

November 2022 in “Research Square (Research Square)”

Seasonal changes affect hair growth genes in Angora goats, possibly influencing mohair quality.

research Differential Expression of Keratin and Keratin-Associated Proteins Linked with Hair Loss in Spontaneously Mutated Inbred Mice

July 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Hair loss in certain mice is linked to changes in keratin-related genes.

research Spatiotemporal Expression and Haplotypes Identification of KRT84 Gene and Their Association with Wool Traits in Gansu Alpine Fine-Wool Sheep

February 2024 in “Genes”

The KRT84 gene is linked to better wool quality in Gansu Alpine Fine-wool sheep.

research Organization and Expression of Hair Follicle Genes

48 citations, July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair growth is controlled by specific gene clusters and proteins, and cysteine affects hair gene expression in sheep.

research Hair Keratin KRT81 Is Expressed in Normal and Breast Cancer Cells and Contributes to Their Invasiveness

24 citations, April 2017 in “Oncology Reports”

The hair keratin gene KRT81 is found in both normal and breast cancer cells and helps them invade surrounding tissues.

research From Genotoxic Stresses to Skin Damage: Distinct, Novel Mechanisms of Skin and Hair Damage in Chemo/Radiation Therapy

April 2017 in “Journal of Investigative Dermatology”

Chemotherapy and radiation therapy cause skin and hair damage by altering gene expression and signaling pathways.

research Expression Profiling Reveals Genes Involved in the Regulation of Wool Follicle Bulb Regression and Regeneration in Sheep

19 citations, April 2015 in “International Journal of Molecular Sciences”

The research identified genes and pathways important for sheep wool growth and shedding.

research p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis

19 citations, December 2015 in “Journal of Investigative Dermatology”

The protein p53 directly reduces the production of Keratin 17, a skin and hair protein, in rats with radiation dermatitis.

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

17 citations, May 2012 in “Journal of biological chemistry/The Journal of biological chemistry”

Hairless protein affects hair follicle structure by regulating the Dlx3 gene.

research Mammalian Keratin-Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments

65 citations, September 2014 in “BMC genomics”

Different hair types in mammals are linked to variations in specific protein genes, with changes influenced by their living environments.

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Related Terms

Research

research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter

research The Microanatomy, Cell Replication, and Keratin Gene Expression of Hair Follicles During a Photoperiod-Induced Growth Cycle in Sheep

research DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

research A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms

research DNA Dioxygenases TET Regulate Keratin Gene Expression and Enhancer Networks Within Lineage-Specific Gene Loci During Epidermal and Hair Follicle-Specific Keratinocyte Differentiation

research Revisiting the Significance of Keratin Expression in Complex Epithelia

research Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression

research Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases?

research Comparative Genomics of the Keratin-Associated Protein Gene Clusters in Human, Chimpanzee, and Baboon

research Differential Gene Expression Profiles in Fetal Skin of Rex Rabbits with Different Wool Density

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Revisiting the Significance of Keratin Expression in Complex Epithelia

research Evaluation of Gene Expression Patterns in Micrografts Demonstrates Induction of Catagen-Like Processes During Storage

research Identification of the Keratin-Associated Protein 22-2 Gene in Capra Hircus and Its Association with Cashmere Traits

research Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in Mouse Skin

research The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family

research Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

research Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

research Differential Expression of Keratin and Keratin-Associated Proteins Linked with Hair Loss in Spontaneously Mutated Inbred Mice

research Spatiotemporal Expression and Haplotypes Identification of KRT84 Gene and Their Association with Wool Traits in Gansu Alpine Fine-Wool Sheep

research Organization and Expression of Hair Follicle Genes

research Hair Keratin KRT81 Is Expressed in Normal and Breast Cancer Cells and Contributes to Their Invasiveness

research From Genotoxic Stresses to Skin Damage: Distinct, Novel Mechanisms of Skin and Hair Damage in Chemo/Radiation Therapy

research Expression Profiling Reveals Genes Involved in the Regulation of Wool Follicle Bulb Regression and Regeneration in Sheep

research p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

research Mammalian Keratin-Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments

research Isolation and Characterization of a Novel Hair Follicle-Specific Gene, Hacl-1

research Downregulation of mRNAs Encoding Keratin-Associated Proteins in the Tongue of Mice Fed a High-Fat Diet

research Wool Keratin-Associated Protein Genes in Sheep: A Review