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    Glossary Keratin 16

    protein providing structural support in skin, hair, and nails

    Keratin 16 (K16) is a type of protein found in the skin, hair, and nails that helps provide structural support and resilience. It is particularly important in the body's response to stress or injury, as it is upregulated in conditions like psoriasis and certain types of alopecia, where the skin or hair follicles are damaged.

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    1. Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin. The Journal of Cell Biology · 1994 · 94 citations
    2. Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle Journal of Investigative Dermatology · 2002 · 87 citations
    3. Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation The Journal of Cell Biology · 1998 · 79 citations
    4. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 1999 · 53 citations
    5. cDNA Cloning, Expression, and Assembly Characteristics of Mouse Keratin 16 Journal of Biological Chemistry · 1998 · 32 citations
    6. Overexpression of human keratin 16 produces a distinct skin phenotype in transgenic mouse skin Biochemistry and Cell Biology · 1995 · 25 citations
    7. The ‘melanocyte-keratin’ mystery revisited: neither normal human epidermal nor hair follicle melanocytes express keratin 16 or keratin 6<i>in situ</i> British Journal of Dermatology · 2009 · 8 citations
    8. Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino-Acid Composition and Repeat Structure 2007 · 51 citations
    9. Exploring the effects of wetting and free fatty acid deposition on an atomistic hair fiber surface model incorporating Keratin Associated Protein 5-1 2022
    10. Keratins 6, 16, and 17 in Health and Disease: A Summary of Recent Findings Current Issues in Molecular Biology · 2024 · 37 citations
    11. Krtap16, Characterization of a New Hair Keratin-associated Protein (KAP) Gene Complex on Mouse Chromosome 16 and Evidence for Regulation by Hoxc13 Journal of Biological Chemistry · 2004 · 47 citations
    12. Abstract 5022: Keratin15 (Krt15) + are radio resistant and tumor-initiating cells in the mouse small intestine Cancer Research · 2017
    13. Relative Amounts of Keratin 17 Are Higher Than Those of Keratin 16 in Hair-Follicle-Derived Tumors in Comparison with Nonfollicular Epithelial Skin Tumors Journal of Investigative Dermatology · 1995 · 31 citations
    14. Distinct mutations in human basic hair keratins 1 and 6 cause monilethrix: Implications for protein structure and clinical phenotype Journal of Investigative Dermatology · 1999
    15. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
    16. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    17. Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and its Relevance for the Pachyonychia Congenita Phenotype Journal of Investigative Dermatology · 2000 · 88 citations
    18. Building Models for Keratin Disorders 2012 · 4 citations
    19. Peer Review #1 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)" 2013
    20. Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia Development · 2001 · 114 citations
    21. Tunable Keratin Hydrogels for Controlled Erosion and Growth Factor Delivery Biomacromolecules · 2015 · 106 citations
    22. Development and optimization of biotinoyl tripeptide-1 loaded solid lipid nanoparticles for protection against heat induced hair damage DergiPark (Istanbul University) · 2026
    23. Trichohyalin is a Potential Major Autoantigen in Human Alopecia Areata Journal of Proteome Research · 2010 · 66 citations
    24. Pitx2, a β-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro Journal of dermatological science · 2009 · 51 citations
    25. A new type of pachyonychia congenita. PubMed · 2001 · 10 citations
    26. The Effect of Ruby Laser Light on Cellular Proliferation of Epidermal Cells Annals of Plastic Surgery · 1999 · 9 citations
    27. Stage-Specific Embryonic Antigen-4 (SSEA-4) as a Distinguishing Marker between Eccrine and Apocrine Origin of Ducts of Sweat Glands Journal of Investigative Dermatology · 2017 · 3 citations
    28. Resolution of the plantar hyperkeratosis of pachyonychia congenita during chemotherapy for Ewing sarcoma British Journal of Dermatology · 2013 · 2 citations
    29. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris) Scientific reports · 2020 · 2 citations
    30. Co-Expression Pattern of Artemis Serine 516 Phosphorylation with Indicators Involving in Differentiation, Proliferation and Apoptosis of Human Anagen Hair Follicles: An Immunofluorescence Double-Staining Study Frontiers in bioscience · 2023