Hair Follicle Markers, Expression and Modulation: Studies on Human Scalp Skin Grafts

    February 2010 in “ Journal of the American Academy of Dermatology ”
    TLDR Activating cAMP and ATP improves hair growth and strength.
    The study utilized a model of human scalp skin grafts to investigate the roles and interactions of different hair follicle components. By applying molecules that activate cAMP and ATP to scalp biopsies, researchers observed significant changes in hair follicle markers. cAMP stimulation increased keratin 14, 15, and 16 in the outer root sheath, enhancing hair growth and anchoring quality. Additionally, collagen IV and laminin-332 levels rose, indicating a stronger basement membrane and improved communication between the outer root sheath and dermal sheath. ATP induction modulated markers like beta-1 integrin, fibronectin, Ki67, and P63, suggesting better cell matrix adhesion and signaling, and potentially benefiting hair renewal and growth cycle maintenance. The findings supported the model's suitability for studying hair follicle component modulation, crucial for hair vitality and regeneration.
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