47 citations
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May 2020 in “Cardiovascular Research” This review explores how sex differences influence the pathophysiology, incidence, and treatment outcomes of ischaemic heart disease, and emphasizes the need for more sex-specific research.
26 citations
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July 2007 in “Biochemical Pharmacology” This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.
19 citations
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April 2019 in “Veterinary dermatology” This study observed that oclacitinib, combined with oral glucocorticoids, achieved rapid and lasting clinical remission in four dogs with refractory juvenile-onset ischaemic dermatopathy, suggesting oclacitinib's potential as a useful immunosuppressive treatment in such cases.
14 citations
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November 2019 in “Mediators of inflammation” This study found that adipose-derived stem cell-conditioned media improved skin flap survival following ischemia/reperfusion injury in mice by increasing cell proliferation and the number of hair follicles, mediated by IL-6.
12 citations
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May 2019 in “Molecular Medicine Reports” This study demonstrated that Forsythiaside A improved survival and reduced neurological deficits in rats with cerebral ischemic injury, potentially through activating Nrf2 and reducing ER stress pathways.
8 citations
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July 2022 in “BMC neuroscience” In this study, intranasal delivery of hair follicle-derived stem cells improved neurological function and reduced brain damage in a rat model of ischemic stroke.
8 citations
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May 2020 in “Anais Brasileiros de Dermatologia” This study found that serum ischemia-modified albumin levels were significantly higher in patients with telogen effluvium compared to healthy controls, suggesting a potential role of oxidative stress in the condition's pathogenesis.
8 citations
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January 2019 in “Turkish journal of medical sciences” This study found that ischemia-modified albumin (IMA) may be a promising biomarker of oxidative stress in patients with alopecia areata, offering better potential compared to other oxidative stress markers.
6 citations
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May 2022 in “Medicina-lithuania” This review discusses ischemia-modified albumin as a potential new marker of oxidative stress in dermatological diseases but reports no new clinical findings.
4 citations
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December 2017 in “International Journal of Biomedicine” In this study, the introduction of autofibroblasts into ischemic wounds was found to be slightly less favorable for regenerative histogenesis compared to a dermal equivalent with heterofibroblasts, with minor differences in epidermis thickness, collagen fiber area, and blood vessel area.
3 citations
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January 2023 in “Dermatology Practical & Conceptual” In this study, the researchers reported that ischemia-modified albumin and IMA/albumin levels may not effectively predict disease severity in patients with alopecia areata.
1 citations
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December 2017 in “Turkderm” This study investigated the factors affecting androgenetic alopecia and found no significant correlation between androgenetic alopecia and ischemia-modified albumin levels in young male subjects.
1 citations
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January 2015 in “Journal of Dermatology and Venereology” This study concluded that androgenetic alopecia may predict ischemic heart disease, and recommended that patients with AGA be screened for coronary artery disease.
1 citations
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January 2015 in “Der pharmacia lettre” This study found that neurosteroids might play a role in the neuroprotective effects of ischemic postconditioning by reducing brain infarct size and improving motor performance and memory in mice.
In this case study, ischemic stroke occurred in a 20-year-old male taking finasteride for hair loss, with multiple genetic predispositions for thrombosis; while causality is uncertain, clinicians should exercise caution when prescribing finasteride to patients with thrombotic risk factors.
October 2025 in “Journal of Veterinary Clinics” In this case study, a Pomeranian was diagnosed with vaccine-induced ischemic dermatopathy, where different medication regimens gradually improved hair regrowth, though some lesions persisted after tapering treatment.
March 2025 in “Anatomy & Cell Biology” This study found that hair follicle stem cell-derived secretome mitigated cell death, apoptosis, and inflammation while upregulating neurotrophic factors in astrocytes exposed to oxygen-glucose deprivation, an in vitro ischemic stroke model, suggesting potential therapeutic benefits in stroke recovery.
October 2023 in “Sovremennye tehnologii v medicine” This research found that LSE transplantation positively affects wound healing by promoting granulation tissue growth and minimizing cosmetic defects in ischemic non-healing wounds during preclinical studies. Additionally, the proposed smoothing coefficient helps assess the degree of wound bed filling with developing tissue.
This review examines the physiology of skin flap necrosis and various substances studied to improve flap viability, noting that promising results are mostly from animal studies, with nitroglycerin already tested in humans.
January 2023 in “Mansoura Medical Journal” This study suggests that increased levels of ischemia-modified albumin, indicating oxidative stress, are associated with greater severity of acne vulgaris.
December 2021 in “Journal of Rheumatic Diseases” In this case report, a 13-year-old girl with pediatric systemic lupus erythematosus experienced rare ischemic vaso-occlusive retinopathy as a first symptom, and early interventions improved her visual acuity and fever but did not fully restore vision.
February 2010 in “Journal of The American Academy of Dermatology” A woman's nail separation was likely caused by poor blood flow, and a treatment for similar conditions might help.
12 citations
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March 2017 in “Arteriosclerosis, thrombosis, and vascular biology” This study in male mice found that testosterone provides strong protection against skin necrosis after ischemia, working through its estrogenic and androgenic derivatives to enhance skin survival and revascularization, with 17β-estradiol being notably more effective than dihydrotestosterone.
4 citations
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February 2023 in “Research Reports in Clinical Cardiology” This study found that the ACE gene DD genotype and D allele are linked to an increased risk of hypertensive IHD complications, with dyslipidemia also identified as a significant risk factor for ischemic heart disease.
2 citations
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September 2018 in “Tissue Engineering Part A” This study found that injecting xeno-free, three-dimensional cell masses from human adipose-derived stem cells improved blood perfusion and preserved limb function in mice without causing tumors or toxicity, suggesting potential for treating severe ischemic diseases.
1 citations
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February 2021 in “Benha Journal of Applied Sciences” This study found that ischemia-modified albumin (IMA) levels were significantly higher in patients with male pattern androgenetic alopecia compared to healthy controls, and these levels correlated with AGA duration and severity.
1 citations
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January 2014 in “Hair transplant forum international” This article discusses patient preferences for the follicular unit extraction (FUE) method in hair transplantation, highlighting its benefits of rapid recovery and comfortable post-operative experience but reports no new clinical results.
In this case report, the authors detail a successful management of early scalp ischemia after hair transplantation using the FLOW protocol, which emphasizes cause correction, local vasodilation, oxygenation optimization, and wound care, resulting in recovery without necrosis.
January 2025 in “Mansoura Medical Journal” This study examined serum ischemia-modified albumin levels in men with androgenic alopecia compared to healthy controls and found no diagnostic value, though higher levels were associated with more severe alopecia, indicating potential involvement in disease progression.
June 2024 in “Benha Journal of Applied Sciences” This study suggests that ischemia-modified albumin may play a role in premature hair graying and vasogenic erectile dysfunction, potentially serving as indicators of susceptibility and severity.