Ischemia-Modified Albumin: A Potential New Marker of Oxidative Stress in Dermatological Diseases

May 2022 in “ Medicina-lithuania ”

Mircea Tampa, Cristina Iulia Mitran, Mădălina Irina Mitran, Andreea Amuzescu, Clara Matei, Simona Roxana Georgescu

ischemia-modified albumin oxidative stress psoriasis acne vulgaris vitiligo alopecia areata androgenetic alopecia IMA acne male pattern baldness

TLDR IMA may indicate oxidative stress in skin and hair disorders, but more research is needed.

The document reviews 24 original articles that evaluated ischemia-modified albumin (IMA) as a potential marker of oxidative stress in various dermatological diseases, including skin disorders like psoriasis, acne vulgaris, and vitiligo, and hair disorders such as alopecia areata and androgenetic alopecia. The majority of these studies found higher IMA levels in patients compared to control groups, suggesting that IMA could be a marker of oxidative stress. However, the correlation between IMA levels and disease severity or duration is not conclusive. The document concludes that further research with larger participant numbers is needed to fully understand the potential biological implications of IMA in dermatological diseases.

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research Evaluation of Serum Ischemia Modified Albumin Level in Male Patients with Androgenetic Alopecia

1 citations , February 2021 in “Benha Journal of Applied Sciences”

research Ischemia-Modified Albumin as a Possible Marker of Oxidative Stress in Patients with Telogen Effluvium

8 citations , July 2020 in “Anais Brasileiros de Dermatologia”

Higher levels of ischemia-modified albumin in telogen effluvium patients may indicate oxidative stress.

research The Impact of Oxidative Stress in Androgenic Alopecia in Women

7 citations , March 2020 in “Postepy Dermatologii I Alergologii”

Oxidative stress plays a role in female pattern baldness, causing an imbalance between harmful and protective elements in the body.

research Ischemia-Modified Albumin as a New Biomarker in Predicting Oxidative Stress in Alopecia Areata

8 citations , January 2019 in “Turkish journal of medical sciences”

Ischemic modified albumin could be a new indicator of oxidative stress in people with alopecia areata.

research Evaluation of Ischemia-Modified Albumin Level and Parameters Related to Oxidative Stress in Early Onset Androgenetic Alopecia

1 citations , December 2017 in “Turkderm”

People with a family history of hair loss are more likely to experience it, and the severity of hair loss is linked to insulin resistance. The connection between early hair loss and oxidative stress needs more investigation.

research Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond?

30 citations , July 2017 in “BioEssays”

Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

research The Role of Micronutrients in Alopecia Areata: A Review

63 citations , May 2017 in “American Journal of Clinical Dermatology”

People with alopecia areata often have lower levels of vitamin D, zinc, and folate, but more research is needed to understand if supplements can help treat it.

research Stress-Related Skin Disorders

67 citations , July 2016 in “Reviews in Endocrine and Metabolic Disorders”

Stress can worsen skin conditions by affecting hormone levels and immune response.

research Oxidative Stress in Androgenetic Alopecia

13 citations , January 2016 in “PubMed”

People with a common type of hair loss have higher stress levels in their body, and treatments that reduce this stress could help.