TLDR Higher IMA levels in male AGA patients, especially if obese, may link AGA to metabolic and heart issues.
The study evaluated serum ischemia modified albumin (IMA) levels in male patients with androgenetic alopecia (AGA) and compared them to healthy controls. It involved 80 participants divided into four groups: 30 obese AGA patients, 30 non-obese AGA patients, 10 obese controls, and 10 non-obese controls. Results showed significant differences in IMA levels between AGA patients and controls, with higher levels in obese patients compared to non-obese patients. The study suggested that obesity and AGA both contribute to increased IMA levels, which correlated with AGA duration and severity. Elevated IMA levels, known as a diagnostic indicator of myocardial ischemia, might link AGA to metabolic disorders such as metabolic syndrome and cardiovascular risk.
19 citations,
December 2011 in “PubMed” Inflammation and immunity play a key role in androgenetic alopecia, with better treatment outcomes in certain immune-positive cases.
28 citations,
March 2007 in “Journal of The European Academy of Dermatology and Venereology” At least 87% of Indian men experience hair loss, with type II being most common and severity increasing with age.
50 citations,
January 2007 in “PubMed” Minoxidil 2% and 5% are common treatments for female pattern hair loss, with other options including anti-androgens, oral contraceptives, and hair transplantation.
115 citations,
September 2000 in “The Lancet” Early hair loss may indicate risk of insulin resistance.
1 citations,
December 2017 in “Turkderm” People with a family history of hair loss are more likely to experience it, and the severity of hair loss is linked to insulin resistance. The connection between early hair loss and oxidative stress needs more investigation.
Early-onset baldness is linked to genetics, lifestyle, and can indicate higher risk for heart and metabolic diseases, and affects mental health.
31 citations,
November 2014 in “Journal of Endocrinological Investigation” Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.
6 citations,
May 2022 in “Medicina-lithuania” IMA may indicate oxidative stress in skin and hair disorders, but more research is needed.
8 citations,
May 2020 in “Anais Brasileiros de Dermatologia” Higher levels of ischemia-modified albumin in telogen effluvium patients may indicate oxidative stress.
