Association Between ACE I/D Gene Polymorphism and Dyslipidemia in Hypertensive Patients with Ischemic Heart Disease Complication Among Ethiopian Population

The study conducted at Debre Tabor Referral Hospital with 140 participants (70 hypertensive IHD patients and 70 healthy controls) found that the ACE DD genotype is significantly more prevalent in IHD patients, with an odds ratio of 2.72, indicating a higher risk of IHD complications. Patients with the DD genotype also had higher systolic and diastolic blood pressure. Dyslipidemia, characterized by lower HDL-C and higher TC, TG, and LDL-C levels, was more common in IHD patients. The study suggests that the ACE DD genotype may increase the risk of hypertensive IHD complications and is associated with dyslipidemia, although no significant relationship was found between ACE gene I/D polymorphisms and dyslipidemia in the study group.