Association Between ACE I/D Gene Polymorphism and Dyslipidemia in Hypertensive Patients with Ischemic Heart Disease Complication Among Ethiopian Population

This study investigated the association between ACE I/D gene polymorphism and dyslipidemia in hypertensive patients with ischemic heart disease (IHD) in an Ethiopian population. Conducted as a hospital-based case-control study with 70 hypertensive IHD patients and 70 healthy controls, the research found that the ACE -DD genotype and D allele were significantly more prevalent in patients, suggesting a genetic predisposition to IHD complications. Additionally, dyslipidemia was identified as a major risk factor, being significantly higher in patients than in controls. The findings highlight the importance of genetic and lipid profile assessments in managing IHD risk.