2 citations
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June 2024 in “International Journal of Drug Delivery Technology” This review describes advanced drug delivery systems for dithranol aimed at overcoming stability issues and skin irritation seen in conventional formulations, highlighting options like nanoparticles and liposomes for improved psoriasis treatment.
1 citations
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November 2024 in “Archives of Dermatological Research” The authors discuss that hair loss affecting the occipital scalp is understudied and may be caused by factors like movement irritation and clothing occlusion; this lack of data can lead to missed diagnoses and inadequate treatment.
1 citations
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December 2021 in “The Open Dermatology Journal” This study found that a herbal hair oil formulation from various plants showed good hair growth and weight without irritation, suggesting potential for improving hair growth.
August 2025 in “Tropical Journal of Natural Product Research” This study found that aerosols formulated with celery extract and candlenut oil significantly stimulated hair growth in rabbits without causing skin irritation, suggesting their potential as natural and safe alternatives for treating alopecia.
February 2025 in “ACS Applied Materials & Interfaces” This study found that a novel choline-based valproic acid ionic liquid significantly enhances transdermal penetration and promotes hair regrowth without causing irritation or toxicity, offering a promising treatment option for alopecia.
January 2025 in “ARC Journal of Clinical Case Reports” This case report suggests that using encapsulated retinol in polylysine may effectively treat actinic keratosis with minimal irritation, potentially providing a safer alternative for frequent use.
December 2024 in “International Journal of Scientific Reports” This study found that OZiva+ advanced hair growth serum significantly increased hair follicle length and showed no irritation, indicating it may be a safer alternative to traditional hair loss treatments like minoxidil.
September 2024 in “Journal of the American Academy of Dermatology” This study found that a new compounded topical solution for alopecia was clinically tolerable and did not cause irritation, while also showing potential to enhance hair growth through fibroblast proliferation and gene expression.
May 2024 in “Journal of biomaterials science. Polymer ed.” This study found that three-layer dissolving microneedles for delivering Minoxidil showed improved skin drug penetration and reduced irritation risk compared to traditional Minoxidil cream, suggesting a promising alternative for alopecia areata treatment.
January 2020 in “Revista da Sociedade Portuguesa de Dermatologia e Venereologia” This study reports that frontal fibrosing alopecia in Brazilian patients is common in postmenopausal women and often associated with hypothyroidism and facial irritation from cosmetic products.
October 2018 in “Springer eBooks” The document concludes that various topical medications are effective for skin conditions but often cause skin irritation as a side effect.
In this study, researchers developed isotretinoin-loaded Delonix polymeric nanoparticles that target hair follicles and found they effectively sustained drug release, reduced IL-6 production in vitro without inhibiting P. acnes, and may prevent isotretinoin-related skin irritation in vivo in Wistar rats.
July 2017 in “Journal of Young Pharmacists” In this study, the ethyl acetate fraction of Nothopanax scutellarium leaves showed a mild irritation effect but promoted hair growth and increased hair diameter in rabbits.
January 2016 in “Mercer University Libraries (Mercer University)” This study found that an anhydrous gel formulation containing sertaconazole nitrate effectively penetrated the stratum corneum for treating fungal infections without causing irritation.
August 2002 in “Dermatologic Surgery” This study found that topical fluridil increased the anagen percentage in men with androgenetic alopecia without causing irritation or systemic side effects.
46 citations
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April 1977 in “Southern Medical Journal” In this study, five women with minoxidil-induced hypertrichosis achieved complete hair removal using a calcium thioglycolate depilatory agent, with minimal or no skin irritation.
33 citations
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January 2022 in “Scientific Reports” This study found that loading CoQ10 into a protransfersomal emulgel improved its stability and anti-ageing effects in UV radiation skin-aged induced-mice, without causing skin irritation.
22 citations
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July 2006 in “Indian Journal of Pharmaceutical Sciences” This study evaluated four minoxidil gel formulations for alopecia treatment, finding similar drug release across membranes and stability over three months, with no skin irritation observed in mice.
21 citations
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January 2023 in “Biomaterials Science” This study investigated the use of dissolving microneedle patches to improve the skin-lightening effects of alpha-arbutin and resveratrol, finding that the patches enhanced intradermal delivery and slightly decreased the melanin index without affecting skin hydration or causing irritation over 24 hours.
21 citations
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September 2013 in “Current medicinal chemistry” This study found that co-drugs synthesized from hydroquinone and tranexamic acid improved skin targeting and deposition, with reduced irritation and enhanced efficacy for treating hyperpigmentation.
16 citations
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January 2023 in “Journal of Cosmetic Dermatology” This study found that micro-needling combined with topical 5-fluorouracil (5-FU) was more effective in treating vitiligo patches than topical tacrolimus, with significant improvement observed in six patients, although it caused mild side effects like erythema and irritation.
15 citations
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November 2019 in “Cutaneous and Ocular Toxicology” This study investigated a liposomal hydrogel system for delivering minoxidil and tretinoin to treat androgenic alopecia, finding that the system enhanced skin permeation of minoxidil while retaining tretinoin on the skin and was non-irritating in animal tests, suggesting its potential effectiveness.
14 citations
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February 2021 in “International Journal of Pharmaceutics” In this study, applying deer antler velvet extract-loaded niosomes and microspicules serum to the scalp significantly improved hair growth, melanin content, and skin hydration over 14 to 30 days without causing skin irritation.
14 citations
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March 2014 in “Journal of the Society of Cosmetic Scientists of Korea” This study suggests that ethanol extracts from ten selected Korean herb medicines reduced inflammatory markers in a cell model and did not cause skin irritation in human testing, indicating potential cosmetic use for irritation prevention.
9 citations
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August 2024 in “Cureus” This study reviewed existing knowledge and research, observing that ketoconazole shampoo is a safe and effective treatment for scalp seborrheic dermatitis, significantly improving irritation and scaling while maintaining low relapse rates and minimal side effects.
7 citations
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January 1987 in “Archives of Dermatology” This study reports that over 70% of responding dermatologists prescribed topical minoxidil, but a small percentage accounted for most prescriptions and few reported complications beyond local irritation.
4 citations
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April 2018 in “Journal of Investigative Dermatology” This study suggests that hydroxypinacolone retinoate (HPR) may be an effective alternative to tretinoin for anti-aging skin treatments, offering similar collagen production benefits without increased skin irritation.
4 citations
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March 2017 in “Zenodo (CERN European Organization for Nuclear Research)” The study formulated a hair application Ayurvedic herbal oil using various plant materials, including Neem and Amla, and reported that all evaluated parameters, such as specific gravity and irritation tests, were acceptable and within standard limits.
4 citations
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January 2016 in “Journal of analytical & bioanalytical techniques” This study evaluated a hair growth gel with Hibiscus rosa sinensis, Eclipta alba, and Solanum nigrum extracts, demonstrating consistent homogeneity, 5 α-reductase inhibitory activity, and no skin irritation.
3 citations
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August 2019 in “Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran dan Ilmu Kesehatan” In this study on New Zealand white rabbits, the researchers reported that a hair tonic formula combining bitter melon leaf and carrot extracts resulted in optimal hair growth, particularly at a 3:1 ratio and a concentration of 3%, without causing irritation.