Potential of Delonix Polymeric Nanoparticles Containing Isotretinoin for Acne Treatment

The study developed isotretinoin-loaded Delonix (IST-DLX) polymeric nanoparticles to improve acne treatment by targeting hair follicles and reducing skin irritation. The DLX polymer, derived from Delonix regia seeds, was characterized and used to create nanoparticles with a size of 215-232 nm and encapsulation efficiency over 25%. These nanoparticles sustained IST release, with 37% released in 48 hours, and showed targeted accumulation in hair follicles. In vitro and in vivo tests demonstrated that IST-DLX nanoparticles reduced IL-6 production in macrophage cells and prevented inflammatory erythema in Wistar rats, unlike free IST. The findings suggested that DLX polymer could be a promising drug delivery system for acne treatment.