Potential of Delonix Polymeric Nanoparticles Containing Isotretinoin for Acne Treatment

    June 2018
    Abayomi Tolulope Ogunjimi
    Studysummary In this study, researchers developed isotretinoin-loaded Delonix polymeric nanoparticles that target hair follicles and found they effectively sustained drug release, reduced IL-6 production in vitro without inhibiting P. acnes, and may prevent isotretinoin-related skin irritation in vivo in Wistar rats.
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    Research cited in this study 5

    1. Iontophoresis-Targeted, Follicular Delivery of Minoxidil Sulfate for the Treatment of Alopecia Journal of Pharmaceutical Sciences · 2013
    2. Polymeric Nanoparticles-Based Topical Delivery Systems for the Treatment of Dermatological Diseases Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2013
    3. Chitosan Microparticles for Sustaining the Topical Delivery of Minoxidil Sulphate Journal of Microencapsulation · 2011
    4. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    5. The Human Sebocyte Culture Model Provides New Insights Into Development and Management of Seborrhoea and Acne Dermatology · 1998