This study reported that the HG3 formulation of a Ketoconazole anti-dandruff gel exhibited superior drug release and antifungal efficacy without causing skin irritation, compared to other formulations tested.
Safflower extract in nanostructured carriers was more effective than minoxidil for hair growth without irritating skin.
January 2012 in “Case reports in pediatrics” This case study reports the first instance of localized acquired hypertrichosis in a pediatric patient following splint application after forearm surgery, with hair growth returning to normal within eight months.
January 1988 in “Chemical and Pharmaceutical Bulletin” This study found that ointments containing indomethacin and its calcium salt showed potent anti-inflammatory effects on rat paw edema and arthritis with minimal skin irritation, suggesting potential for clinical use.
July 1979 in “Archives of Dermatology” This case report describes a 68-year-old woman with benign mucous membrane pemphigoid and unusual keratotic plaques on her extremities, associated with longstanding mouth and eye symptoms and phalangeal swelling.
April 2023 in “Journal of Drug Delivery Science and Technology” This study reported that optimized transfersomes and their gel form significantly improved transdermal delivery and hair growth promotion of minoxidil in C57BL/6 mice compared to commercial formulations.
January 2023 in “Pharmaceutics” In this study, researchers developed a new topical atraric acid formulation, AA-TF#15, which showed a significantly higher drug penetration and increased hair regrowth in mice compared to minoxidil and finasteride treatments, suggesting its potential effectiveness for treating scalp androgenic alopecia.
January 2023 in “International Journal of Trichology” This review discusses the positioning of low alcohol or alcohol-free topical minoxidil for managing androgenetic alopecia in Indian clinical practice and reports no new clinical results.
December 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Topical finasteride is promising for hair loss with minimal side effects but needs more research and approval.
June 2023 in “Journal of the American Academy of Dermatology” This study reviewed existing research on the potential link between chemical hair relaxers and uterine cancer, highlighting the scarcity of epidemiological studies and stressing the importance of understanding straightening methods in communities of color.
49 citations
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May 2018 in “Journal of the American Academy of Dermatology” This letter discusses the limited treatment options for pediatric alopecia areata and the lack of controlled studies for therapies like systemic and off-label immunosuppressive drugs, without reporting new clinical results.
48 citations
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November 2017 in “Journal of the American Academy of Dermatology” Tofacitinib 2% ointment helped hair regrow in 3 out of 10 patients with alopecia areata, but caused side effects like scalp irritation and raised cholesterol in some.
10 citations
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January 2013 in “International Journal of Research in Pharmaceutical Sciences” This study found that a microemulsion containing extracts of Hibiscus rosa sinensis and Murraya koenigii was non-irritating and more effective at controlling hair loss than a standard marketed formulation.
1 citations
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August 2021 in “International journal of scientific research in science and technology” This study evaluated a polyherbal hair oil, containing natural ingredients like Hibiscus and Aloe Vera in a coconut oil base, for its phytochemical properties, antimicrobial activity, and potential to reduce dandruff and hair loss while promoting hair growth.
This chapter reviews nanocarriers for acne therapy, highlighting their ability to reduce lesions and inflammation while improving the safety and effectiveness of treatment, though no new clinical results are reported.
April 2017 in “Journal of Investigative Dermatology” This study found that 10% carbamide peroxide significantly reduced acne lesions compared to a vehicle solution, suggesting it as an effective and safe alternative to benzoyl peroxide for treating mild to moderate acne.
34 citations
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September 1985 in “Contact Dermatitis” Minoxidil can cause skin irritation like eczema and rash in some users.
2 citations
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January 1998 in “Dermatology” Stopping forehead irritation and using hydrocortisone helped a man's skin, Martinique has lower melanoma rates, a man had an allergy to a specific antifungal, another had unexplained cysts, certain drugs can cause skin reactions without always being interrelated, a link between Fanconi anemia and a skin condition was suggested, high levels of a certain protein may play a role in a type of psoriasis, and there's a need to study the connection between scalp pain and hair loss.
4 citations
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November 2012 in “Dermatitis” A man got severe skin irritation after using marking nut sap for hair loss.
May 2025 in “Dermatology Online Journal” This report describes a rare case of eyelash overgrowth and eyelid irritation in a woman treated with erlotinib for lung adenocarcinoma, highlighting a potential side effect of the drug.
11 citations
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January 2022 in “Brazilian Oral Research” This study found that XP-endo Finisher R was approximately twice as effective as passive ultrasonic irrigation in removing root filling material from curved mesiobuccal canals of maxillary molars.
6 citations
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June 2013 in “Toxicological Research” This study found that topical valproate has minimal potential to cause skin irritation, suggesting it can be applied safely to human skin.
4 citations
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January 2009 in “International journal of trichology” Minoxidil topical foam is a better, less irritating treatment for hair loss.
January 2026 in “New Journal of Chemistry” This study synthesized calcium citrate nanoparticles to improve the solubility and reduce the irritation of minoxidil solutions for treating androgenetic alopecia.
This review highlights that hair care products can cause adverse effects like irritation dermatitis and allergic contact eczema but does not report new clinical findings.
17 citations
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August 2002 in “Dermatologic Surgery” This study found that topical fluridil increased the anagen hair percentage in men with androgenetic alopecia without causing irritation or systemic absorption over 9 months.
11 citations
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June 2018 in “Annales de dermatologie et de vénéréologie” This narrative review discusses adverse reactions associated with hair care products, specifically irritation dermatitis and allergic contact eczema, and suggests the need for attention to common allergens like PPD, GMTG, and ammonium persulphate.
11 citations
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January 2014 in “International Journal of Trichology” This study observed that patients using Erol(®) Energy shampoo and tonic reported improved symptoms of scalp irritation and rated product tolerance as good to excellent.
5 citations
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January 1999 in “Journal of dermatological treatment” This study found that while Bioré pore strips effectively removed microcomedones and trichostatic bundles on the nose without causing irritation, they were less effective than cyanoacrylate extraction.
3 citations
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January 1989 in “Journal of Japan Oil Chemists Society” This study examined the effects of six surfactants on hair and scalp, finding varying irritation levels and impacts on protein denaturation and scalp turnover time, with AMT suggested as a good detergent.