Transdermal Delivery of Valproate–Choline Ionic Liquid Induces Hair Regrowth

February 2025 in “ ACS Applied Materials & Interfaces ”

Sai Gao, Xueqing Cheng, Yunhao Feng, Dingqi Wu, Zeren Han, Qian He, Ming Zhang, Qiong Dai, Liyun Zhang, Chaoyong Liu, Yunfeng Lu

valproic acid choline-based valproic acid ionic liquid VPA-IL transdermal delivery Wnt/β-catenin signaling pathway hair papilla cell proliferation PCNA K14 loricrin hair follicle stem cell activity alopecia VPA hair regrowth hair loss treatment

Studysummary This study found that a novel choline-based valproic acid ionic liquid significantly enhances transdermal penetration and promotes hair regrowth without causing irritation or toxicity, offering a promising treatment option for alopecia. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigates the transdermal delivery of Valproate–Choline Ionic Liquid for inducing hair regrowth. The research utilized various materials and methods, including human hair papilla cells, keratinocytes, and endothelial cells, to assess the efficacy of the treatment. The study highlights the potential of this ionic liquid formulation in promoting hair regrowth, although specific results and the number of participants involved in the study are not detailed in the provided text.

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