Transdermal Delivery of Valproate–Choline Ionic Liquid Induces Hair Regrowth

February 2025 in “ ACS Applied Materials & Interfaces ”

Sai Gao, Xueqing Cheng, Yunhao Feng, Dingqi Wu, Zeren Han, Qian He, Ming Zhang, Qiong Dai, Liyun Zhang, Chaoyong Liu, Yunfeng Lu

valproic acid choline-based valproic acid ionic liquid VPA-IL transdermal delivery Wnt/β-catenin signaling pathway hair papilla cell proliferation PCNA K14 loricrin hair follicle stem cell activity alopecia VPA hair regrowth hair loss treatment

TLDR A new treatment using valproic acid helps regrow hair safely.

The study investigates the transdermal delivery of Valproate–Choline Ionic Liquid for inducing hair regrowth. The research utilized various materials and methods, including human hair papilla cells, keratinocytes, and endothelial cells, to assess the efficacy of the treatment. The study highlights the potential of this ionic liquid formulation in promoting hair regrowth, although specific results and the number of participants involved in the study are not detailed in the provided text.

View this study on pubs.acs.org →

Discuss this study in the Community →

Research cited in this study

15 / 15 results

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Frontal Fibrosing Alopecia: An Update on the Hypothesis of Pathogenesis and Treatment

38 citations , January 2019 in “International Journal of Women's Dermatology”

The document concluded that more research is needed to find the best treatment for Frontal fibrosing alopecia.

research Transcutaneous Implantation of Valproic Acid-Encapsulated Dissolving Microneedles Induces Hair Regrowth

68 citations , March 2018 in “Biomaterials”

Tiny needles with valproic acid can effectively regrow hair.

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

research Red Ginseng Extract Promotes Hair Growth in Cultured Human Hair Follicles

49 citations , November 2014 in “Journal of Medicinal Food”

Red Ginseng Extract may help human hair grow by activating growth pathways and blocking negative effects of certain hormones.

Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

research Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

37 citations , February 2014 in “Journal of Dermatology”

Valproic acid increases hair count in men with hair loss.

research Valproic Acid Promotes Human Hair Growth in In Vitro Culture Model

48 citations , June 2013 in “Journal of Dermatological Science”

Valproic acid may help hair grow and could be a safe treatment for hair loss.

research Hair Growth-Promoting Effect of Aconiti Ciliare Tuber Extract Mediated by the Activation of Wnt/β-Catenin Signaling

45 citations , September 2012 in “Life Sciences”

Aconiti Ciliare Tuber extract may help hair grow by activating a specific cell signaling pathway.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations , July 2012 in “Journal of Investigative Dermatology”

Wnt ligands are crucial for hair growth and repair.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.

research The Pathogenesis of Primary Cicatricial Alopecias

150 citations , October 2010 in “The American Journal of Pathology”

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

research Evaluation and Treatment of Male and Female Pattern Hair Loss

203 citations , December 2004 in “Journal of The American Academy of Dermatology”

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

71 citations , January 2004 in “Dermatology”

Oral finasteride works better than topical minoxidil for hair growth, both are safe.

research Molecular Biology of Hair Morphogenesis: Development and Cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

Similar Research

5 / 458 results

research The Role of Vitamins and Minerals in Hair Loss: A Review

134 citations , December 2018 in “Dermatology and Therapy”

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

research A Systematic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia

14 citations , October 2020 in “Natural Products and Bioprospecting”

Various treatments, including FDA-approved drugs, natural products, and oral supplements, can help with hair loss, but a patient's medical history and potential allergies should be considered when choosing a treatment.

research Response to: Rethinking Biotin Therapy for Hair, Nail, and Skin Disorders

4 citations , August 2018 in “Journal of The American Academy of Dermatology”

The authors agree that biotin may help certain hair disorders but lacks evidence for use in healthy people and call for more research.

research A Review of the Use of Biotin for Hair Loss

78 citations , January 2017 in “Skin appendage disorders”

Biotin supplements may improve hair and nail growth in people with certain deficiencies or conditions, but there's not enough evidence to recommend it for healthy individuals.

research Biotin And Biotinidase Deficiency

166 citations , November 2008 in “Expert Review of Endocrinology & Metabolism”

Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.