Transdermal Delivery of Valproate–Choline Ionic Liquid Induces Hair Regrowth

February 2025 in “ ACS Applied Materials & Interfaces ”

Sai Gao, Xueqing Cheng, Yunhao Feng, Dingqi Wu, Zeren Han, Qian He, Ming Zhang, Qiong Dai, Liyun Zhang, Chaoyong Liu, Yunfeng Lu

valproic acid choline-based valproic acid ionic liquid VPA-IL transdermal delivery Wnt/β-catenin signaling pathway hair papilla cell proliferation PCNA K14 loricrin hair follicle stem cell activity alopecia VPA hair regrowth hair loss treatment

Studysummary This study found that a novel choline-based valproic acid ionic liquid significantly enhances transdermal penetration and promotes hair regrowth without causing irritation or toxicity, offering a promising treatment option for alopecia.

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