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    Glossary Interferon-gamma

    protein that activates immune cells to fight infections and cancer

    Interferon-gamma (IFN-γ) is a type of protein called a cytokine that plays a crucial role in the immune system. It is produced primarily by T cells and natural killer (NK) cells and helps activate macrophages, enhance antigen presentation, and boost the body's defense against infections and cancer.

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    1. Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin PLOS ONE · 2013 · 24 citations
    2. Failure to induce alopecia areata in C3H/HeJ mice with exogenous interferon gamma Journal of experimental animal science · 2006 · 13 citations
    3. Evaluation of Serum Toll-Like Receptor 4, Interferon Gamma, and Interleukin-17 Levels in Iraqi Patients with Alopecia Areata European journal of ecology, biology and agriculture. · 2026
    4. Effect of diode pumping solid state laser with wavelength 589 nm on gene expression of interlukine-2 and interferon-gamma Lowercase in human T-lymphocytes Journal of the Pakistan Medical Association · 2024
    5. Alopesi areata hastalarında serum interferon-gama, tümör nekrozis faktör-alfa, interlökin-13, interlökin-17 ve transforming growth faktör-beta düzeylerinin değerlendirilmesi 2016
    6. Diagnostic Significance of MIG (Monokine Induced by Gamma Interferon) and IP-10 (Interferon gamma-induced protein 10) Chemokines in Alopecia Areata Medical Science Journal for Advance Research · 2025
    7. 0046 Antagonizing interferon-gamma receptor-1 signaling with topical SAMiRNA in human scalp skin protects hair follicles from immune privilege collapse and keratinocyte apoptosis Journal of Investigative Dermatology · 2026
    8. Interferon in the treatment of cutaneous T-cell lymphoma Dermatologic Therapy · 2003 · 107 citations
    9. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008 · 69 citations
    10. Treatment of Alopecia Areata with Anti-Interferon-γ Antibodies Journal of Investigative Dermatology Symposium Proceedings · 2005 · 16 citations
    11. Intrinsic Modulators of Hair Growth: Roles of Growth Factors, Cytokines, Chemokines, and Interferons International Journal of Trichology · 2025
    12. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018 · 418 citations
    13. Hair follicle immune privilege and its collapse in alopecia areata Experimental dermatology · 2020 · 134 citations
    14. Role of Cytotoxic T Cells in Chronic Alopecia Areata Journal of Investigative Dermatology · 2000 · 127 citations
    15. Natural killer cells in atopic and autoimmune diseases of the skin Journal of Allergy and Clinical Immunology · 2010 · 91 citations
    16. Understanding autoimmunity of vitiligo and alopecia areata 2016 · 74 citations
    17. Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of α-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells Endocrinology · 2005 · 60 citations
    18. An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation Journal of Allergy and Clinical Immunology · 2018 · 58 citations
    19. Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application Stem Cell Research & Therapy · 2020 · 53 citations
    20. Morphea: progress to date and the road ahead Annals of Translational Medicine · 2021 · 50 citations
    21. The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications Cells · 2021 · 37 citations
    22. An Animal Model of Trichloroethylene-Induced Skin Sensitization in BALB/c Mice International journal of toxicology · 2015 · 36 citations
    23. Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice Journal of Nanobiotechnology · 2022 · 29 citations
    24. Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege 2013 · 27 citations
    25. Thyroid antibodies in Hashimoto’s thyroiditis patients are positively associated with inflammation and multiple symptoms Scientific Reports · 2024 · 23 citations
    26. Lack of efficacy of apremilast in 9 patients with severe alopecia areata Journal of the American Academy of Dermatology · 2017 · 23 citations
    27. Phenotypic Analysis of T-Cells in Extensive Alopecia Areata Scalp Suggests Partial Tolerance 2005 · 21 citations
    28. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    29. The Functional Relevance of the Type 1 Cytokines IFN-γ and IL-2 in Alopecia Areata of C3H/HeJ Mice Journal of Investigative Dermatology Symposium Proceedings · 2005 · 20 citations
    30. Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata eLife · 2023 · 18 citations