More Expression of IL-17 Than IFN-γ from CD49a-Negative Tissue-Resident Memory T Cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients According to the Foxp3+ mTregs Depletion

    September 2019 in “ Journal of Investigative Dermatology ”
    Ji Woong Kim, Y. Cho, H. Kim, G. Kim, Hirata Ki
    TLDR IL-17 and certain immune cells are linked to more severe alopecia areata.
    The study investigated the role of tissue-resident memory T (Trm) cells and memory regulatory T cells (mTregs) in the pathogenesis of chronic alopecia areata (AA) by examining 9 patients. It found that IL-17 expression and CD8+CD49a- Trm cell infiltration were significantly higher in the hair follicle bulge and bulb regions of AA lesions, correlating with more severe histopathological grades. Conversely, IFN-γ expression was lower, and Foxp3+ mTregs were decreased as the severity increased. These findings suggested that IL-17 and CD8+CD49a- Trm cells played a significant role in the immunopathogenesis of AA, potentially offering new insights into the disease's mechanisms.
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