More Expression of IL-17 Than IFN-γ from CD49a-Negative Tissue-Resident Memory T Cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients According to the Foxp3+ mTregs Depletion

    September 2019 in “ Journal of Investigative Dermatology ”
    Ji Woong Kim, Y. Cho, H. Kim, G. Kim, Hirata Ki
    TLDR IL-17 and certain immune cells are linked to more severe alopecia areata.
    The study investigated the role of tissue-resident memory T (Trm) cells and memory regulatory T cells (mTregs) in the pathogenesis of chronic alopecia areata (AA) by examining 9 patients. It found that IL-17 expression and CD8+CD49a- Trm cell infiltration were significantly higher in the hair follicle bulge and bulb regions of AA lesions, correlating with more severe histopathological grades. Conversely, IFN-γ expression was lower, and Foxp3+ mTregs were decreased as the severity increased. These findings suggested that IL-17 and CD8+CD49a- Trm cells played a significant role in the immunopathogenesis of AA, potentially offering new insights into the disease's mechanisms.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  39 upvotes 1 year ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 5 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

    Related Research

    5 / 5 results