TLDR Higher levels of certain DNAs in blood may indicate hair follicle damage in alopecia areata patients.
This study investigated the clinical significance of cell-free DNA (cfDNA) and circulating DNAs of disease-associated cytokines in patients with alopecia areata (AA). Serum samples from 63 AA patients and 32 healthy controls were analyzed using droplet digital polymerase chain reaction. The study found that circulating DNAs of CXCL9, CXCL11, IL-15, IFN-γ, and JAK2 were significantly higher in AA patients compared to healthy controls. These elevated DNA levels may indicate damage to hair follicles in AA patients, suggesting their potential as biomarkers for the disease.
40 citations,
August 2022 in “Frontiers in immunology” Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.
191 citations,
May 2018 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.
14 citations,
April 2021 in “International journal of molecular sciences” Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.
December 2023 in “International journal of multidisciplinary research and analysis” SH-MSCs gel reduced IL-6 and increased TGF-β, suggesting it could treat alopecia.
4 citations,
January 2023 in “Skin health and disease” Blocking Janus kinase 1 helps stop inflammation and regrow hair, making it a good treatment for hair loss from alopecia areata.
January 2024 in “International Journal of Molecular Sciences” Blocking the protein CXCL12 with a specific antibody can increase hair growth in common hair loss conditions.
December 2023 in “International journal of multidisciplinary research and analysis” SH-MSCs gel can effectively treat alopecia by increasing IL-10 and decreasing TNF-α gene expression.
