Elevation of Circulating DNAs of Disease-Associated Cytokines in Serum Cell-Free DNA from Patients with Alopecia Areata

    April 2024 in “ Bioscience trends ”
    Soichiro Sawamura, Tselmeg Mijiddorj Myangat, Ikko Kajihara, Katsunari Makino, Jun Aoi, Shinichi Masuguchi, Satoshi Fukushima
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    TLDR Higher levels of certain DNAs in blood may indicate hair follicle damage in alopecia areata patients.
    This study investigated the clinical significance of cell-free DNA (cfDNA) and circulating DNAs of disease-associated cytokines in patients with alopecia areata (AA). Serum samples from 63 AA patients and 32 healthy controls were analyzed using droplet digital polymerase chain reaction. The study found that circulating DNAs of CXCL9, CXCL11, IL-15, IFN-γ, and JAK2 were significantly higher in AA patients compared to healthy controls. These elevated DNA levels may indicate damage to hair follicles in AA patients, suggesting their potential as biomarkers for the disease.
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