1 citations
,
November 2022 in “Pharmaceutical research” In this study, the authors found that applying hypobaric pressure to the skin significantly increases the transdermal permeation of large molecules by enhancing diffusion, despite the associated skin stretching and hair follicle enlargement not fully explaining this effect.
38 citations
,
December 2006 in “Journal of Investigative Dermatology” Keratin patterns in hair follicles help understand hair growth and potential hair and nail disorders.
15 citations
,
July 2004 in “Journal of morphology” This study analyzes the fine structure and protein distribution in monotreme hairs, finding similarities with other mammals and detailing unique immunocytochemical features in their inner root sheaths.
18 citations
,
September 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that vitamin D-upregulated protein 1 (VDUP1) might play a unique role in regulating the differentiation of epidermal cells.
71 citations
,
June 2005 in “Journal of Investigative Dermatology” This study demonstrates that PAD1 and PAD3 are involved in hair follicle differentiation, while PAD1 and PAD2 may play a role in the physiology of sweat glands and arrector pili muscles.
2 citations
,
January 2001 in “Biomedical Research” This study found that peptidylarginine deiminase type III and trichohyalin are coincidentally expressed in the infant rat hair follicle, but trichohyalin deimination occurs after their expression during development.
29 citations
,
September 2014 in “American Journal of Dermatopathology” This study found that horizontal sections of scalp biopsies in patients with Central Centrifugal Cicatricial Alopecia often reveal follicular miniaturization, inflammation, and scarring, which can guide personalized treatment.
30 citations
,
November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This study discovered that the lipid in human hair follicles is mainly located in the hair cuticle and keratinized inner root sheath, distinct from sebaceous and epidermal lipids, suggesting a potential role as a "hair barrier.
6 citations
,
April 1996 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” This study suggests that TGF-alpha may function in an autocrine or juxtacrine manner rather than promoting cell proliferation during hair growth cycles in ferrets and sheep.
22 citations
,
September 2000 in “Journal of Investigative Dermatology” This study found that mu-crystallin gene expression in mouse skin is highest during the anagen phase of hair development, suggesting its possible role in hair follicle growth.
1 citations
,
April 2025 in “Materials Today Communications” In this study, researchers developed a composite electrospun dressing with fiber gradient changes that mimics skin's natural structure, demonstrating enhanced wound healing, collagen deposition, and reduced fibrosis and scarring in both in vitro and in vivo experiments.
26 citations
,
December 1990 in “Journal of Biological Chemistry” In this study, elevated mRNA levels for serine-rich ultra high sulfur proteins were observed during active hair growth phases in mice, particularly in the forming hair structures and upper skin layers.
36 citations
,
August 2011 in “Journal of dermatological science” This article examines the role and composition of integral hair lipids in forming a protective barrier similar to the skin's epidermal lipid layer and reports no new findings about their effects.
21 citations
,
December 2015 in “European journal of cell biology” In this study, researchers demonstrated that follicular tight junctions in porcine skin form a barrier to nanoparticle penetration, particularly in upper regions, which supports its use as a model for human skin.
13 citations
,
September 2012 in “Cell & tissue research/Cell and tissue research” In this study, researchers found that the pCLCA2 protein is expressed in specific areas of pig skin, but its role in skin structure or function remains unclear.
20 citations
,
September 2004 in “Journal of Anatomy” This study suggests that the structure and function of the inner root sheath in mammalian hair may have evolved from simpler forms seen in monotremes, aiding in hair exit without damaging the epidermis.
October 2024 in “International Journal of Comprehensive Veterinary Research.” In this study, researchers examined the skin of neonatal rabbits and found that most hair follicles were in the terminal stage, with hair shafts protruding through the epidermis, but noted the absence of sweat glands.
13 citations
,
January 2022 in “Microvascular Research” This study found that high-resolution laser speckle contrast imaging devices provide good reproducibility for assessing skin perfusion in mice but not for measuring haemoglobin oxygenation.
April 2017 in “Journal of Investigative Dermatology” This study identified that in mice, sweat gland development is directed by mesenchymal signals that suppress SHH-production, while in humans, this occurs through a BMP spike in embryonic development.
20 citations
,
July 2005 in “Experimental dermatology” This study found that the fuzzy mutation in mice is linked to both structural hair defects and accelerated hair follicle cycling, influencing the regulation of hair cycle phases such as catagen and anagen.
17 citations
,
June 2012 in “Journal of experimental zoology. Part B, Molecular and developmental evolution” This review explores theories on the evolution of hair from synapsid scales and glands, proposing mechanisms supported by comparative studies, but reports no new experimental findings.
May 2002 in “Journal of Investigative Dermatology” New findings on hair keratin, wound healing, and skin blistering were presented.
September 2012 in “대한피부과학회지” In this study, Dsc 1 was highly expressed in certain layers of fetal epidermis and hair follicle but not in basal cells or oral mucosa, indicating its potential role in maintaining epithelial integrity.
39 citations
,
January 2016 in “PubMed” This review discusses the role of epidermal differentiation complex genes and epigenetic mechanisms in skin development and certain diseases, emphasizing their potential for improving drug development and delivery systems but provides no new experimental results.
17 citations
,
November 2000 in “Journal of Investigative Dermatology” ZPK helps skin cells mature and may affect skin health.
13 citations
,
April 1982 in “The Journal of Dermatology” This study found that poly(adenosine diphosphate-ribose) synthesis in human skin varies by cell type and condition, with distinct patterns in psoriatic, cancerous, and normal tissues.
May 2024 in “Journal of colloid and interface science” This study developed a bilayer bionic skin scaffold that mimics the skin's structure to resist microbial invasion and enhance wound healing, with in vivo animal studies showing improved collagen deposition, neovascularization, and hair follicle formation.
June 2025 in “Journal of Cosmetic Dermatology” This case study reported promising hair regrowth in a child with morphea en coup de sabre using fractional CO2 laser-assisted exosome therapy, but further research is needed to validate these findings due to its single-subject design.
40 citations
,
April 1995 in “Journal of Cutaneous Pathology” This study found that androgen receptor expression varied across different types of skin appendage tumors, with specific expression patterns noted in sebaceous and sweat gland tumors but absent in hair follicle tumors.
26 citations
,
August 2014 in “Veterinary Dermatology” This study found that sphynx cats exhibit hair follicle dysplasia with abnormal hair shaft production, but without a reduction in the number of follicles, similar to murine KRT 71 mutants.