Histological and Dermatoscopic Description of Sphynx Cat Skin

August 2014 in “ Veterinary Dermatology ”

David W. Genovese, Tammy L. Johnson, Ken E. Lamb, Wallace D. Gram

hair follicle dysplasia infundibular hyperkeratosis keratin 71 KRT 71 mutants hair shaft keratinization

Studysummary This study found that sphynx cats exhibit hair follicle dysplasia with abnormal hair shaft production, but without a reduction in the number of follicles, similar to murine KRT 71 mutants.

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research A Splice Variant in KRT71 Is Associated with Curly Coat Phenotype of Selkirk Rex Cats

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This study found an association between a splice site variant in the KRT71 gene and curly hair in Selkirk Rex cats, identifying a significant locus on chromosome B4.

research A Missense Mutation Within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis

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research The Naked Truth: Sphynx and Devon Rex Cat Breed Mutations in KRT71

75 citations , October 2010 in “Mammalian genome”

In this study, specific genetic polymorphisms in the KRT71 gene were associated with hairless and curly phenotypes in Sphynx and Devon Rex cats.

research Identification of the Rat Rex Mutation as a 7-Bp Deletion at Splicing Acceptor Site of the Krt71 Gene

45 citations , January 2010 in “Journal of Veterinary Medical Science”

This study identified a mutation in the keratin 71 gene that causes curly hair in certain rats, advancing our understanding of hair formation.

research Hair Loss Disorders in Domestic Animals

45 citations , December 2009 in “Veterinary dermatology”

The book is recommended for its new scientific information and balanced treatment options for hair loss in domestic animals.

research Morphologic and Molecular Characterization of Two Novel Krt71 (Krt2-6g) Mutations: Krt71 Rco12 and Krt71 Rco13

51 citations , December 2006 in “Mammalian Genome”

research An Overview on Congenital Alopecia in Domestic Animals

32 citations , November 2006 in “Veterinary dermatology”

This review discusses the various forms of congenital alopecia in domestic animals and highlights the need for improved classification due to limited understanding and rarity; it reports no new clinical results.

research A Small Deletion Hotspot in the Type II Keratin Gene mK6irs1/Krt2-6g on Mouse Chromosome 15, a Candidate for Causing the Wavy Hair of the Caracul (Ca) Mutation

53 citations , October 2003 in “Genetics”

This study identified a mutation hotspot in the caracul (Ca) locus of mice, implicating the mK6irs1/Krt2-6g gene in hair formation and potentially human hair and skin diseases.

research Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency

42 citations , September 2003 in “Journal of Investigative Dermatology”

A missing mK6irs1 gene causes hair loss in mice.

research K6irs1, K6irs2, K6irs3, And K6irs4 Represent The Inner-Root-Sheath-Specific Type II Epithelial Keratins Of The Human Hair Follicle

130 citations , April 2003 in “Journal of Investigative Dermatology”

This study reports the cloning and expression details of two new human type II keratins, K6irs3 and K6irs4, in the hair follicle's inner root sheath, suggesting a distinct functional role related to hair structure.

research Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments

686 citations , February 2002 in “Current Opinion in Cell Biology”

Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.

research A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

45 citations , March 2001 in “Journal of Investigative Dermatology”

This study identified a new cytokeratin, mK6irs, specifically expressed in the inner root sheath of mouse hair follicles, distinguishing it as a member of the type II cytokeratin family.