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Glossary Inflammatory Acne

occurs when clogged hair follicles cause red, swollen lesions

Inflammatory acne, also known as acne inflammatoria, is a type of acne characterized by red, swollen, and often painful lesions. These lesions occur when hair follicles become clogged with oil and dead skin cells, leading to bacterial infection and an immune response that causes inflammation. This condition can result in papules, pustules, nodules, or cysts, and often requires more intensive treatment than non-inflammatory acne.

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research Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

520 citations , January 2017 in “AIMS biophysics”

This review discusses the effects of photobiomodulation, particularly its potential to reduce inflammation in various conditions, but it does not report new clinical findings.

Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

research Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment

278 citations , March 2013 in “Gut”

In this study, nearly 5% of anti-TNF-treated patients with IBD developed psoriasiform skin lesions, with smoking identified as a main risk factor, and ustekinumab proved highly effective in severe cases.

research Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

249 citations , November 2018 in “Cell”

TNFα helps grow and maintain liver cells in 3D culture for a long time.

research Inflammatory priming enhances mesenchymal stromal cell secretome potential as a clinical product for regenerative medicine approaches through secreted factors and EV-miRNAs: the example of joint disease

118 citations , April 2020 in “Stem Cell Research & Therapy”

This study found that adipose-derived mesenchymal stromal cell secretome, particularly when preconditioned with IFNγ, significantly influences cell motility and anti-inflammatory responses, enhancing its potential as a regenerative therapy.

research Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk

102 citations , July 2007 in “Genes & Development”

This study found that maternal PPARγ is essential for preventing the production of inflammatory lipids in mouse milk, which can otherwise cause inflammation, alopecia, and growth retardation in nursing pups.

Hyaluronidase Modulates Inflammatory Response and Accelerates Cutaneous Wound Healing

research Hyaluronidase Modulates Inflammatory Response and Accelerates the Cutaneous Wound Healing

98 citations , November 2014 in “PLoS ONE”

In this study, bovine testes hyaluronidase accelerated wound healing in vitro and in vivo by enhancing cellular proliferation, reepithelialization, and modulating inflammation in rat models.

research miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes

90 citations , September 2020 in “Journal of Investigative Dermatology”

This study found that increasing the levels of specific microRNAs from the miR-17∼92 cluster improved wound healing in mice by reducing inflammation, suggesting a potential therapeutic approach for chronic wounds.

research Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases

88 citations , August 2019 in “Frontiers in immunology”

This review discusses the role of tyrosine kinase signaling pathways in autoimmune and inflammatory skin diseases and reports no new clinical results, highlighting ongoing research into small-molecule tyrosine kinase inhibitors as potential treatments.

research The many faces of interleukin-17 in inflammatory skin diseases

77 citations , April 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

This article reviews the role of IL-17 in inflammatory skin disorders and highlights its potential therapeutic targeting in both neutrophilic and lymphocyte-mediated conditions, reporting no new experimental results.

research The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases

70 citations , October 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

This review discusses the JAK-STAT pathway and the use of FDA-approved JAK inhibitors for autoimmune and inflammatory diseases but reports no new research findings.

Short-Chain Fatty Acids from Cutibacterium Acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes

research Short-Chain Fatty Acids from Cutibacterium acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes

70 citations , February 2019 in “The journal of immunology/The Journal of immunology”

This study found that short-chain fatty acids produced by the skin microbe Propionibacterium acnes may drive inflammatory gene expression in sebocytes, potentially contributing to acne.

research Effects of finasteride in patients with inflammatory chronic pelvic pain syndrome: a double-blind, placebo-controlled, pilot study

65 citations , March 1999 in “Urology”

This study found that finasteride significantly reduced symptom severity scores in patients with inflammatory chronic pelvic pain syndrome, though its effect on pain was not significant.

research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

59 citations , July 2015 in “Journal of Immunology”

This study found that disrupting inflammasome signaling by eliminating caspase-1 and -11 in mice reduced skin inflammation and delayed the onset of disease, highlighting their role in skin disease pathogenesis.

research The spectrum of inflammatory skin disease following jejuno-ileal bypass for morbid obesity

51 citations , October 1981 in “British Journal of Dermatology”

This study found that in patients who underwent jejuno-ileal bypass for morbid obesity, dapsone was effective in treating inflammatory skin lesions and joint symptoms when other antibiotics failed.

research Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity

47 citations , June 2012 in “Genes & Development”

This study found that maternal consumption of a western diet in mice led to toxic milk production, causing inflammation and alopecia in nursing neonates due to Toll-like-receptor activation.

research Inflammatory Tinea Capitis (Kerion) Mimicking Dissecting Cellulitis.

44 citations , March 1991 in “International Journal of Dermatology”

This article presents two cases of tinea capitis in postpubertal individuals highlighting the importance of early treatment to prevent scarring and permanent hair loss; it reports no new clinical results.

Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial

research Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial – Biochemical)

41 citations , February 2021 in “Cureus”

This study found that in males with mild COVID-19, treatment with dutasteride, along with standard therapy, may reduce viral shedding and inflammation compared to placebo.

research NUDT15,FTO, andRUNX1genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases

40 citations , January 2017 in “Intestinal Research”

This study found that among Japanese IBD patients, the NUDT15 p.Arg139Cys variant was significantly associated with thiopurine-induced leukopenia and severe hair loss, suggesting its genotyping is important for predicting these adverse events.

Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

research Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

40 citations , December 2012 in “PLoS ONE”

This study found that selective deletion of Ctip2 in epidermal keratinocytes in adult mice leads to atopic dermatitis-like inflammation and suggests Ctip2 plays a crucial role in skin barrier maintenance and inflammatory regulation.

Epidermal Keratinocytes Initiate Wound Healing and Pro-Inflammatory Immune Responses Following Percutaneous Schistosome Infection

research Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection

39 citations , January 2015 in “International journal for parasitology/International Journal for Parasitology”

This study found that Schistosoma mansoni cercariae stimulate epidermal keratinocytes in mice, initiating pro-inflammatory responses and barrier repair mechanisms akin to those in wound healing.

research Inflammatory and Anti-Inflammatory Parameters in PCOS Patients Depending on Body Mass Index: A Case-Control Study

32 citations , October 2023 in “Biomedicines”

This study found that chronic low-grade inflammation exists independently of excess weight or obesity in women with PCOS, with notable increases in specific cytokines such as IL-9, MCP-3, and MIP-1α.

research Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes

32 citations , December 2009 in “Archives of Dermatological Research”

In this study, DHT was associated with increased production of proinflammatory cytokines IL-6 and TNF-α in cultured sebocytes, suggesting a role in acne pathophysiology beyond sebum production.

research Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers

31 citations , December 2023 in “Middle East Fertility Society Journal”

This review discusses the relationship between polycystic ovary syndrome and inflammation, highlighting various inflammatory markers, but reports no new clinical results.

research Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice

29 citations , June 2018 in “Scientific Reports”

In this study, Alox15 knockout mice exhibited disrupted skin integrity and increased inflammation, suggesting that Alox15-mediated resolvin D2 production is crucial for maintaining skin homeostasis by suppressing inflammation.

research Inflammatory tinea capitis mimicking dissecting cellulitis in a postpubertal male: a case report and review of the literature

29 citations , April 2013 in “Mycoses”

This case report describes a rare instance of tinea capitis in a 19-year-old male, initially misdiagnosed as dissecting cellulitis, highlighting the need for accurate diagnosis to prevent scarring alopecia.

research Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes—A Putative Contributor to Dry Skin Dermatoses

26 citations , August 2018 in “Journal of Investigative Dermatology”

This study found that TRPV3 activation in human sebocytes inhibits lipid synthesis and triggers proinflammatory cytokine expression, suggesting a role in the pathogenesis of dry skin-associated inflammatory dermatoses.

research Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?

26 citations , June 2016 in “Journal of Reproductive Immunology”

This study found that in women with polycystic ovary syndrome, xanthine oxidase activity is a useful marker for oxidative stress and is positively correlated with inflammatory markers and cardiovascular disease risk factors.

Diffuse Alopecia Areata Is Associated With Intense Inflammatory Infiltration and CD8+ T Cells in Hair Loss Regions and an Increase in Serum IgE Level

research Diffuse alopecia areata is associated with intense inflammatory infiltration and CD8+ T cells in hair loss regions and an increase in serum IgE level

24 citations , January 2012 in “Indian Journal of Dermatology, Venereology and Leprology”

This study suggests that hypersensitivity and increased serum IgE levels might contribute to the pathogenesis of diffuse alopecia areata through intense local inflammatory infiltration.

research Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines

22 citations , August 2020 in “Molecules”

This study found that applying AGN root extract containing decursin to mouse skin accelerated hair growth and altered inflammatory cytokine levels compared to a control.

Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid, and Saw Palmetto Extract

research Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid and Saw Palmetto Extract

22 citations , August 2009 in “Evidence-based Complementary and Alternative Medicine”

This study found that a composition including Serenoa repens extract and anti-inflammatory agents effectively suppressed inflammation-related gene expression in a keratinocyte model, suggesting a potential dual strategy for treating androgenetic alopecia.