TLDR Women with PCOS have higher xanthine oxidase activity linked to inflammation and heart disease risks.
The 2016 cross-sectional study with 45 PCOS patients and 38 healthy controls found that women with PCOS had higher xanthine oxidase (XO) activity, which was positively correlated with inflammatory markers and cardiovascular risk factors such as triglycerides, fasting plasma glucose, fasting plasma insulin, and insulin resistance. Conversely, superoxide dismutase (SOD) activity was decreased in PCOS patients. The study concluded that XO could be a useful marker for oxidative stress in PCOS and may play a significant role in the condition's pathogenesis and associated metabolic complications.
989 citations,
August 2007 in “The Lancet” PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.
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January 2004 in “Fertility and Sterility” The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.
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