2 citations
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May 1985 in “Environmental Health Perspectives” This report examines the mechanisms by which TCDD affects human epidermal and carcinoma cells, aiming to create a risk assessment model for halogenated aromatic compounds, but presents no new clinical results.
July 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that using exosomes derived from thrombin-pretreated umbilical cord mesenchymal stem cells significantly accelerated wound healing and improved skin regeneration in a mouse model, highlighting their potential as a cell-free therapy for skin injuries.
January 2007 in “The FASEB journal” In this study, keratin hydrogels derived from human hair were found to significantly enhance nerve regeneration in a mouse model, acting effectively as scaffolds by influencing Schwann cell behavior.
16 citations
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October 2018 in “Experimental Dermatology” This study suggests that mesenchymal stem cell therapy may improve cell viability and regulate key signaling pathways in vitro for treating alopecia areata.
3 citations
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September 2020 in “Bladder cancer” In this study, 5α-reductase inhibitors were found to have no significant impact on preventing tumorigenesis or progression in in vitro models of urothelial cancer.
3 citations
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February 2014 in “Advances in Stem Cells” This study concluded that placental mesenchymal stem cells from aborted fetal tissue may serve as an in vitro model for studying spontaneous abortion mechanisms and potential regenerative therapies due to their abnormal gene expression and differentiation capabilities.
August 2026 in “Molecules” This study found that Eucommia ulmoides bark extract shows potential antioxidant and hair follicle-support properties in vitro and in vivo, but further validation is needed to confirm these effects.
August 2021 in “Research Square (Research Square)” This study found that BEO inhibited cell proliferation and inflammatory mediator release in a human keratinocyte acne model and reduced acne lesion severity in a rabbit model, suggesting its potential as a natural alternative to conventional acne treatments.
January 2021 in “Figshare” This study found that metformin may promote hair follicle regeneration by enhancing dermal cell activity in an in vitro mouse model, suggesting potential for treating pattern hair loss.
1 citations
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December 2001 in “Linchuang pifuke zazhi” In this study, certain Chinese herbal medicines were found to significantly stimulate or inhibit hair growth in an in vitro organ culture model of mouse vibrissa follicles.
19 citations
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April 2023 in “Antibiotics” This study found that azelaic acid entrapped in transethosomes exhibited enhanced antidermatophyte activity and improved treatment outcomes in guinea pig models of dermatophytosis compared to free azelaic acid.
2 citations
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January 2025 in “Brazilian Journal of Medical and Biological Research” This study demonstrated that VD3 significantly enhanced the proliferation and differentiation of epidermal stem cells in a murine skin defect model, leading to improved wound healing, potentially through activation of the PI3K signaling pathway.
1 citations
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January 2007 The study found that stratum corneum thickness and total epidermal lipid content influence the permeation rates of certain nonsteroidal anti-inflammatory drugs in various animal skin models, and suggests porcine skin as an effective human replacement in diffusion experiments.
September 2025 in “Arthritis Research & Therapy” In this study, researchers found that the compound BMS-470539 induced a senescence-like state in fibroblasts from systemic sclerosis patients, reducing fibrosis-associated markers in vitro and decreasing skin thickness in a mouse model of skin fibrosis, suggesting a novel therapeutic strategy for managing fibroblast-driven diseases.
May 2025 in “Insights-Journal of Health and Rehabilitation” This study found that Aloe vera and Citrus lemon extracts demonstrated notable antibacterial effects against Propionibacterium acnes in both lab and human skin models, with combined use resulting in a 67% reduction in acne, suggesting potential for future therapeutic applications.
April 2026 in “BMC Biotechnology” This study evaluated a novel synthetic cell-penetrating peptide, DualPep-ALO, finding it promotes hair growth by enhancing follicle cell proliferation, activating regenerative pathways, and reducing inflammation and oxidative stress in vitro and ex vivo, suggesting a promising new topical treatment for hair loss that rivals minoxidil.
April 2024 in “Lasers in medical science” This study found that near-infrared LED therapy enhanced ATP synthesis, reduced reactive oxygen species, and promoted collagen production and hair growth more effectively than white LEDs in human skin cells and a photoaging mouse model.
24 citations
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February 2021 in “Polymers” This study found that urchin-like Ag–Au bimetallic and Ag nanoparticle-decorated PAN mats showed significant antibacterial effects and potential for wound healing in in vitro and in vivo animal models.
20 citations
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May 2023 in “Cancer Nanotechnology” The researchers reported that their novel formulation of pterostilbene-loaded ethoniosomes with folic acid coating effectively targeted lung cancer cells in vitro and demonstrated promising results in animal models, indicating potential for future targeted chemotherapy applications.
10 citations
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July 2023 in “Pharmaceuticals” This study explored the wound healing potential of a natural marine soft coral-derived nanoparticle-based gel in a diabetic excision wound model, finding it effectively regulates proinflammatory cytokines and inhibits enzymes related to wound healing.
4 citations
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April 2011 in “Stem Cell Reviews and Reports” This research describes a two-step culture system for pluripotent mouse ES cells that produces hair follicle-like structures, providing a valuable model to study stem cell differentiation in vitro.
September 2024 in “International Journal of Molecular Sciences” This study found that hot water extract of Hydrangea serrata leaf and hydrangenol promoted hair growth by enhancing 5α-reductase inhibitory activity, stimulating dermal papilla cell growth, and exhibiting anti-inflammatory and anti-androgenic effects in cell cultures, mice, and human skin organoid models.
January 2024 in “Bratislavské lekárske listy/Bratislava medical journal” This study examined the vasorelaxant effects of two similar alkaloids, chloroquine and cinchonine, in a model of smooth muscle contractions induced by phenylephrine. Results are not reported in the abstract.
July 2023 in “International Journal of Molecular Sciences” In this study, Trapa bispinosa Roxb. pericarp extract demonstrated inhibitory effects on 5α-reductase activity both in vitro using LNCaP cells and in vivo in a mouse model of benign prostatic hyperplasia, suggesting its potential role in managing the condition.
29 citations
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October 2020 in “Environmental health perspectives” This study found that several preservatives, including triclocarban and triclosan, showed potential endocrine-disrupting effects on various nuclear receptors in both in silico and in vitro models.
7 citations
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July 2017 in “bioRxiv (Cold Spring Harbor Laboratory)” This study's in silico experiments suggest that the average cell proliferation rate can vary with passage number, highlighting the importance of reporting passage numbers for reproducibility in cell culture studies.
26 citations
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January 2019 in “Experimental Dermatology” This study developed an in vitro system to analyze human skin progenitor cells' ability to form hair peg-like structures, providing insights for engineering hair follicle organoids.
September 2019 in “Journal of Investigative Dermatology” This study developed a 3D skin model with immune and endothelial cells, which may enhance understanding of skin biology and diseases due to its closer approximation to native skin.
June 1967 in “Journal of Cellular Physiology” This study developed an in vitro 3D organoid model using dermal papilla spheroids and found that it enhances growth factor expression and extracellular matrix production, which could aid drug screening for hair regeneration.
29 citations
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April 2003 in “Experimental dermatology” In this study, in vitro growth of human hair follicles did not alter hair keratin expression patterns, maintaining follicle integrity and proper keratinization similar to in vivo conditions.