5α-Reductase Inhibitors Do Not Prevent the Development and Progression of Urothelial Cancer: In Vitro Evidence

    October 2020 in “ Bladder cancer ”
    Yoshika Nagata, T. Goto, Guiyang Jiang, Yuki Teramoto, Hiroshi Miyamoto
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    TLDR 5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.
    The document from December 14, 2020, presents findings from an in vitro study which determined that 5α-reductase inhibitors (5α-RIs) such as dutasteride, finasteride, and epristeride do not prevent the development or progression of urothelial cancer. The study used a human non-neoplastic urothelial cell line and human bladder cancer lines to assess the effects of these drugs. While the androgen receptor antagonist bicalutamide significantly inhibited the proliferation of AR-positive bladder cancer cells, the 5α-RIs did not have a significant effect on inhibiting cell migration or the neoplastic transformation of cells treated with testosterone. The conclusion drawn was that 5α-RIs, even at high doses, do not impact the prevention of tumorigenesis or tumor progression in urothelial cancer.
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