Expression of AR, 5αR1 and 5αR2 in Bladder Urothelial Carcinoma and Relationship to Clinicopathological Factors

September 2017 in “ Life sciences ”

Shuko Hata, Kazue Ise, Abdullah Azmahani, Sachiko Konosu-Fukaya, Keely May McNamara, Fumiyoshi Fujishima, Kaoru Shimada, Koji Mitsuzuka, Yoichi Arai, Hironobu Sasano, Yasuhiro Nakamura

androgen receptor 5α-reductase type 1 5α-reductase type 2 5α-dihydrotestosterone AR 5αR1 5αR2 DHT dihydrotestosterone

TLDR Androgens may influence bladder cancer progression by affecting cellular behavior.

The study investigated the expression of androgen receptor (AR) and androgen-producing enzymes 5α-reductase type 1 (5αR1) and type 2 (5αR2) in bladder urothelial carcinoma and their relationship to clinicopathological factors. It was found that AR, 5αR1, and 5αR2 immunoreactivity decreased with increasing carcinoma grade. In vitro experiments using the T24 bladder carcinoma cell line showed that treatment with the androgen agonist 5α-dihydrotestosterone (DHT) significantly increased AR expression and cell proliferation, but did not affect 5αR1 or 5αR2 expression. This suggests that AR may play a role in bladder cancer progression, potentially explaining the higher incidence in men.

View this study on sciencedirect.com →

Discuss this study in the Community →

Similar Research

6 / 1000+ results

research Mechanism of Action of Avicennia Marina Heartwood Extract and Avicequinone C on Human Dermal Papilla Cells Isolated from Androgenic Alopecia Patients

January 2016

Avicennia Marina extract and avicequinone C can reduce hair loss hormone production and increase hair growth factors, suggesting they could be used to treat androgenic alopecia.

research Theoretical Evaluation of Interaction of Some Dibenzo Derivatives on Both Androgen Receptor and 5-Alpha-Reductase Enzyme

5 citations, January 2022 in “Clinical cancer investigation journal”

Certain Dibenzo derivatives may help treat prostate cancer.

research Inhibition of Skin 5α-Reductase by Oral Contraceptive Progestins In Vitro

78 citations, January 2000 in “Gynecological Endocrinology”

Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.

research Novel Inhibitors of 5α-Reductase

20 citations, February 2002 in “Expert Opinion on Therapeutic Patents”

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

research 5α-Reduced Glucocorticoids: A Story of Natural Selection

46 citations, September 2011 in “Journal of Endocrinology”

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

research Physiology and Medical Treatments for Alopecia

8 citations, April 2020 in “Facial Plastic Surgery Clinics of North America”

Minoxidil, finasteride, and low-level laser light therapy are effective FDA-approved treatments for hair loss.

Expression of AR, 5αR1 and 5αR2 in Bladder Urothelial Carcinoma and Relationship to Clinicopathological Factors

Related Community Posts Join

community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.

community Trying to understand finasteride side effects and post finasteride syndrome

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

community New and Interesting HairLoss Studies/Papers/Reviews

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.