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research 5-Alpha Reductase Inhibitors in Prostate Cancer: From Clinical Trials to Clinical Practice

7 citations , January 2013 in “European Urology”

This study developed solid lipid nanoparticles for delivering a shRNA-encoding plasmid that effectively reduced 5α-reductase enzyme levels in vitro without significant cytotoxicity, suggesting potential therapeutic applications.

Comments Concerning the Real Risk of Sexual Adverse Events Secondary to the Use of 5-Alpha-Reductase Inhibitors

research Comments concerning the real risk of sexual adverse events secondary to the use of 5-ARIs

January 2016 in “Archivio italiano di urologia, andrologia”

This article reviews treatment-induced sexual dysfunctions related to 5-alpha-reductase inhibitors and reports no new results; it highlights the need to better define and understand this controversial topic.

research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome

35 citations , June 2018 in “Urology”

This study of FAERS data suggests that finasteride, particularly at the 1 mg dosage, is associated with a wide range of adverse effects not previously established in long-term studies, especially among younger men.

research Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review

35 citations , April 2013 in “Sexual medicine reviews”

This review found that 5α-reductase inhibitors are associated with slightly increased rates of sexual dysfunction, gynecomastia, and mood disorders, but the true significance and persistence of these effects remain unclear.

research Long-term use of 5α-reductase inhibitors and the risk of male breast cancer

28 citations , August 2014 in “Cancer Causes & Control”

In this study, there was no evidence that using 5α-reductase inhibitors for either short or long durations increased the risk of male breast cancer.

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Community Join

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community Finasteride is a risk in pregnancy with unprotected sex

118 upvotes 6 years ago

Finasteride may pose a risk during pregnancy, so using a condom is recommended if a partner is pregnant. It is advised to stop finasteride before trying to conceive due to potential effects on fetal development.

community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

26 upvotes 5 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.

in Research/Science 9 upvotes 3 years ago

Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.

community Why is Finasteride seen as “scary” for men, but hormonal birth control is totally normalized for women?

in Finasteride/Dutasteride 757 upvotes 1 year ago

Finasteride is seen as risky for men due to side effects like erectile dysfunction, while hormonal birth control for women is normalized despite its side effects. The discussion points out a double standard influenced by societal and gender norms.

community 3 months progress pics (20 days ago)

241 upvotes 2 years ago

A user shared their 3-month hair loss treatment progress using 5% minoxidil, 1mg finasteride, and occasional nizoral. They noted significant progress and plan to continue treatments, with another update at the 6-month mark.

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