Development and Molecular Characterization of Human Placental Mesenchymal Stem Cells from Aborted Fetal Tissue as a Model to Study Mechanism of Spontaneous Abortion

The study focused on isolating and characterizing mesenchymal stem cells (MSCs) from human aborted placental tissue to understand the mechanism of spontaneous abortion. The researchers found that these placenta-derived MSCs (hPMSCs) exhibited high pluripotency, expressing markers like Oct4, Nanog, and Sox2, and demonstrated the ability to differentiate into cardiomyocytes and osteocytes. Notably, there was abnormal expression of genes such as CD 73, CD 100, CD 45, Ki67, and Vimentin in the aborted fetal tissue, suggesting their potential role in pregnancy maintenance. The study concluded that hPMSCs could serve as an in vitro model to study spontaneous abortion mechanisms and hold promise for future regenerative therapies.