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Did you mean Chromatin Immunoprecipitation?

Glossary Chromatin Immunoprecipitation

method to study protein-DNA interactions using specific antibodies

Chromatin Immunoprecipitation (ChIP) is a laboratory technique used to investigate the interaction between proteins and DNA within the cell. By using specific antibodies to target and isolate a protein of interest, researchers can identify the DNA sequences that are bound by this protein, providing insights into gene regulation and epigenetic mechanisms.

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The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

research The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

9 citations , November 2019 in “Scientific reports”

This study isolated a bioactive peptide from Trapa japonica fruit and found that it may protect human dermal papilla cells from DHT-induced stress, suggesting potential for biomedical applications.

research Identification of human hair follicle antigens targeted in the presumptive autoimmune hair follicle disorder alopecia areata and their potential functional relevance in vitro : methods development for isolation and identification of alopecia areata-relevant human hair follicle antigens using a proteomics approach and their functional assessment using an ex vivo hair follicle organ culture model

January 2008 in “Bradford Scholars (University of Bradford)”

This study supports that an antibody response against anagen-specific hair follicle antigens, including trichohyalin and keratin 16, may play a role in alopecia areata.

research In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators

173 citations , January 2014 in “Nature Cell Biology”

This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.

research The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes

56 citations , September 2014 in “Molecular Endocrinology”

This study found that the absence of unliganded vitamin D receptor significantly impairs cWnt and hedgehog signaling pathways necessary for hair cycle initiation in VDR-null mice.

research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

8 citations , July 2022 in “International Journal of Molecular Sciences”

This study found that in estrogen receptor-positive breast cancer cells, 17β-estradiol repressed polyamine oxidase transcription by interacting with AP-1 sites on its promoter.

research The Mammalian Hairless Protein as a DNA Binding Phosphoprotein

6 citations , June 2016 in “Journal of cellular biochemistry”

This study found that the mammalian Hr protein can interact with the p53 pathway by binding to a specific p53 response element, influencing the regulation of genes involved in cell cycle control.

research STAT3 Partly Inhibits Cell Proliferation via Direct Negative Regulation of FST Gene Expression

3 citations , June 2021 in “Frontiers in genetics”

This study found that STAT3 directly inhibited the activity of the sheep FST gene promoter, consequently reducing cell proliferation and promoting a better understanding of hair follicle development mechanisms.

research LncRNA MTC enhances the proliferation of Liaoning cashmere goat skin fibroblasts by modulating GSTM1-ASK1 interaction

March 2024 in “Cytologia”

In this study, researchers observed that melatonin-mediated LncRNA MTC in Liaoning cashmere goat skin fibroblasts enhances cell proliferation by interacting with the GSTM1 protein, affecting its complex formation with ASK1 and thereby inhibiting apoptosis, which may be relevant for improving cashmere growth.

research Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia

May 2021 in “Experimental Cell Research”

In this study, SFRP1 expression was found to be upregulated in hair follicles from men with androgenetic alopecia, with the transcription factor FOXC1 playing a significant role in its regulation.

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation

68 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.

research The Autoimmune Regulator (AIRE), Which Is Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17

24 citations , February 2011 in “The American journal of pathology”

This study found that AIRE, a usually nuclear protein, is expressed in the cytoplasm of human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin 17, potentially impacting ectodermal abnormalities in APECED syndrome.

research Expression of Plectin-1 and Trichohyalin in Human Tongue Cancer Cells

2 citations , January 2018 in “Open journal of stomatology”

This study found that trichohyalin is expressed in cancerous tongue epithelial cells, while plectin-1 expression may indicate malignancy.

research Synchronizing actin and microtubules for axonal branching

3 citations , August 2012 in “Nature Cell Biology”

This study found that the Wnt-β-catenin pathway directly promotes TERT expression in both stem and cancer cells, highlighting a mechanistic link between tumorigenesis and pluripotency.

research Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease

January 2018 in “Stem cell biology and regenerative medicine”

This review discusses how the nuclear lamina integrates biochemical and mechanical signals to influence gene expression and skin homeostasis, but reports no new clinical results.

Watching Hair Grow: Intravital Two-Photon Imaging of Hair Follicle Regeneration in Transgenic Mice

research Watching hair grow

August 2012 in “Nature Cell Biology”

This study shows that the Wnt-β-catenin pathway promotes TERT expression in both stem and cancer cells, linking tumorigenesis with pluripotency.

research Stem and cancer cells Wnt long telomeres

August 2012 in “Nature Cell Biology”

This study provides direct evidence that the Wnt-β-catenin pathway promotes TERT expression in stem and cancer cells, linking tumorigenesis with pluripotency.

BRCA2 in Abscission: Role in Cytokinesis and Recruitment of Abscission Regulators

research BRCA2 in abscission

August 2012 in “Nature Cell Biology”

In this study, researchers found that β-catenin directly promotes TERT expression in stem and cancer cells by interacting with the Tert promoter, illustrating a mechanistic link between tumorigenesis and pluripotency.

Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

research Evidence That the Satin Hair Mutant Gene Foxq1 Is among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 during Hair Follicle Differentiation

65 citations , July 2006 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that overexpression of Hoxc13 in GC13 mouse models affects hair follicle differentiation by interacting with medulla-specific genes, particularly Foxq1, suggesting a regulatory pathway for medulla differentiation.

research c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

60 citations , February 2013 in “Cell reports”

This study demonstrates that c-MYC overexpression in sebaceous glands affects differentiation via a regulatory axis involving the androgen receptor and p53, influencing carcinoma formation outcomes.

research Skin Keratins

54 citations , November 2015 in “Methods in enzymology on CD-ROM/Methods in enzymology”

This chapter reviews keratins in skin epithelia, including their roles in cellular function and disease, and reports no new experimental results.

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

42 citations , July 2007 in “Journal of Biological Chemistry”

This study found that most pathogenic HR mutants associated with atrichia with papular lesions had abolished corepressor activity due to defective interactions with histone deacetylases.

research Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization

29 citations , October 2016 in “Cell death and differentiation”

This study found that in squamous cell carcinomas, the inhibition of the tumor-suppressor function of TAp73β by ΔNp63α occurs through promoter squelching, not direct protein interaction.

research Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity

28 citations , July 2008 in “Developmental Biology”

This study found that the loss of Smad4 in keratinocytes reduces Dsg4 expression via disrupted BMP signaling, contributing to hair follicle degeneration and alopecia.

Inhibition of 3-Methylcrotonyl-CoA Carboxylase Explains the Increased Excretion of 3-Hydroxyisovaleric Acid in Valproate-Treated Patients

research Inhibition of 3‐methylcrotonyl‐CoA carboxylase explains the increased excretion of 3‐hydroxyisovaleric acid in valproate‐treated patients

20 citations , December 2011 in “Journal of inherited metabolic disease”

This study found that valproic acid may interfere with the leucine metabolic pathway by inhibiting 3-methylcrotonyl-CoA carboxylase and biotinidase, which could contribute to side effects like skin rash and hair loss in patients.

Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells

research Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells

14 citations , November 2007 in “Journal of Dermatological Science”

This review discusses the roles of epithelial-mesenchymal interactions and dermal papilla in hair follicle growth and cycling, but it reports no new clinical results.

Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells In Vitro by Forming a Complex With Tcf4 and β-Catenin

research Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin

13 citations , August 2020 in “Frontiers in Cell and Developmental Biology”

This study found that Twist1 and Tcf4 synergistically regulate the hair follicle induction ability of dermal papilla cells by forming a complex with β-catenin, enhancing their biological properties.

research Overexpression of Lnk in the Ovaries Is Involved in Insulin Resistance in Women With Polycystic Ovary Syndrome

11 citations , July 2016 in “Endocrinology”

This study found that higher Lnk expression in PCOS patients may contribute to insulin resistance by inhibiting insulin signaling pathways.

Molecular Functional Analyses Revealed Essential Roles of HSP90 and Lamin A/C in Growth, Migration, and Self-Aggregation of Dermal Papilla Cells

research Molecular functional analyses revealed essential roles of HSP90 and lamin A/C in growth, migration, and self-aggregation of dermal papilla cells

10 citations , May 2018 in “Cell death discovery”

This study found that the interaction between heat shock protein 90 and lamin A/C is crucial for the growth, migration, and self-aggregation of dermal papilla cells, suggesting a potential role in alopecia areata mechanisms.

Increased Retinol-Binding Protein 4 and Anti-RBP4 Antibody in Alopecia Areata

research Increased retinol‐binding protein (RBP) 4 and anti‐RBP4 antibody in alopecia areata

6 citations , June 2011 in “British Journal of Dermatology”

This study found that individuals with alopecia areata had significantly higher serum levels of retinol-binding protein 4 and increased IgG immunoreactivity against it, suggesting a role in the disease's pathogenesis.

The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

research The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

3 citations , February 2022 in “Frontiers in cell and developmental biology”

This study found that the circular RNA circCOL1A1 influences the formation of superior-quality brush hair in white goats by regulating hair follicle stem cell behavior and interacting with the miR-149-5p/CMTM3/AR axis.