Expression of Plectin-1 and Trichohyalin in Human Tongue Cancer Cells

    January 2018 in “ Open journal of stomatology ”
    Isao Tamura, Katsura Ueda, Tetsunari Nishikawa, Aiko Kamada, Tomoharu Okamura, Yoshihisa Matsuda, Kentaro Ueno, Yusuke Yoshikawa, Eisuke Domae, Kazuhiro Tominaga, Shunji Kumabe, Takashi Ikeo, Akio Tanaka
    Studysummary This study found that trichohyalin is expressed in cancerous tongue epithelial cells, while plectin-1 expression may indicate malignancy. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the expression of plectin-1 and trichohyalin in human tongue cancer cells. Plectin-1 was highly expressed in BICR31 tongue cancer cells but not in DOK human tongue epithelial cells, suggesting its potential role as a tumor marker in tongue cancer. Trichohyalin was expressed in both cell types, with stronger expression in BICR31 cells. The findings indicated that plectin-1 might be involved in the malignant transformation of epithelial cells, while trichohyalin's role in tongue cancer required further investigation. Co-immunoprecipitation and western blot analyses did not yield clear results regarding the interaction between plectin-1, trichohyalin, and cytokeratins.
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