February 2026 in “International Journal of Molecular Sciences” In this review, researchers discuss how mitochondria-targeted biophysical priming of autologous biologics, through methods like photobiomodulation and ultrasound, can potentially enhance skin rejuvenation and wound repair by modulating mitochondrial function in skin cells.
November 2022 in “Journal of Investigative Dermatology” This study found that dysregulation of the DNA damage response in stem cells is a common factor of aging, affecting tissues like the skin, brain, kidneys, and intestine.
July 2024 in “Journal of Investigative Dermatology” Bioactive peptides improve graft survival and new hair growth.
172 citations
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May 2018 in “Nature” Mammalian organs regenerate using stem cells and cell plasticity, but this ability declines with age.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that combining UVB irradiation with anti-CD154 antibody improves the survival of hair follicle allografts in a humanized mouse model, suggesting a synergistic effect for allogeneic hair transplantation.
11 citations
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October 2004 in “Journal of Experimental Biology” This review discusses the lasting impact of a 1951 J. Exp. Biol. paper on skin grafting methods and transplantation tolerance, which significantly influenced the field of transplantation biology.
November 2025 in “Advanced Healthcare Materials” This review explores advancements in bioprinting technologies for developing in vitro skin models that replicate immune-mediated skin diseases, highlighting their potential to reduce animal testing and enhance research and product testing capabilities in dermatology.
November 2022 in “Bioengineering” This study developed immortalized cell-based models to screen and evaluate potential hair-care materials by forming hair follicle-like structures that respond to hair growth-promoting compounds.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that apocynin restored COL17A1 expression in human keratinocytes and reduced UVB-induced cellular senescence, DNA damage, and cell cycle arrest.
July 2025 in “Journal of Investigative Dermatology” Solid Lipid Particle technology makes retinol more stable, effective, and gentle on the skin.
June 2025 in “Problems of Cryobiology and Cryomedicine” In this study, the researchers found that tyndallization effectively sterilizes aqueous solutions of hyaluronic acid without diminishing their regenerative properties, and these properties remain intact even at low temperatures, supporting potential applications in cryobiology and cryomedicine.
16 citations
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January 2010 in “Springer eBooks”
5 citations
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September 2016 in “Dermatologic Therapy” This paper reports three cases of hair transplantation using Feily's method, which showed unusual long-lasting dark areas on the scalp, suggesting more than 24 hours of caution might be needed to prevent necrosis.
1 citations
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February 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study describes a new imaging platform for the adult Drosophila midgut, facilitating real-time observation of cell behaviors and dynamics involved in organ renewal.
19 citations
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December 2018 in “Experimental and Molecular Medicine” This study reports that the novel small molecule IM176OUT05, by modifying stem cell metabolism, promoted hair regrowth and increased hair follicle numbers in mice.
7 citations
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July 2023 in “International Journal of Molecular Sciences” In this study, human nucleus pulposus cells treated with hyaluronic acid showed increased proliferation and reduced oxidative stress compared to those treated with EDTA-PBS, suggesting a potential role for hyaluronic acid in enhancing intervertebral disc therapy.
December 2025 in “Journal of Pharma Insights and Research.” This paper reviews the state of knowledge on injectable cryogels, highlighting their unique properties such as shape-memory and mechanical integrity, which allow for minimally invasive delivery via needles and potential applications in oncology and regenerative medicine.
November 2025 in “Bioactive Materials” In this study, researchers developed a DNA/GelMA-based cryogel platform that uses phototherapy to combat MRSA infection and promote scarless wound healing, showing enhanced bactericidal activity, tissue regeneration, and anti-inflammatory effects in vivo, suggesting a promising approach for treating infected skin wounds.
January 2023 in “Advanced Biology” This study observed that DNA methylation dynamics, including global hypermethylation and site-specific changes, influenced gene expression associated with immune activation and PI3K-Akt signaling during esophageal tissue regeneration with acellular grafts.
41 citations
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January 2006 in “Dermatology” This study found that noncultured epidermal cell transplantation is promising for treating stable vitiligo, achieving significant repigmentation and patient satisfaction based on objective and subjective evaluations.
August 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this retrospective study of patients with advanced Merkel cell carcinoma responding to immunotherapy, those treated for 18 months or longer showed better progression-free outcomes compared to shorter treatment durations, indicating potential benefits of extended therapy duration.
January 2012 in “Zhongguo shengwuzhipinxue zazhi” This study found that a complex filling material made from autologous skin fibroblasts and hair keratin significantly improved the appearance of facial wrinkles, suggesting potential for clinical cosmetic applications.
January 2024 in “Wiadomości Lekarskie” This study highlights the role of innate immunity and purinergic signaling in regulating hematopoiesis and hematopoietic stem/progenitor cell specification. The researchers observed that these ancient pathways operate both paracrinally and autocrinally within HSPCs, maintaining their developmental function throughout evolution.
32 citations
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August 2019 in “Nature Communications” In this study, researchers found that alkylating chemotherapy causes hair follicle stem cells to lose their regenerative ability by initially triggering proliferation followed by apoptosis, leading to permanent regeneration loss.
6 citations
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January 2018 in “Advances in experimental medicine and biology” This research reports that Muse cells from human skin can be differentiated into melanocytes, fibroblasts, and keratinocytes, enabling the creation of 3D reconstituted skin, potentially advancing skin reconstruction therapies.
12 citations
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May 2013 in “International Journal of Molecular Sciences” In this study, researchers isolated multipotent stem cells from elderly human epidermis and showed that they could differentiate into neurons using TAT-VHL peptide, suggesting potential for regenerative therapies.
January 2019 in “Springer eBooks” The abstract reports that non-cultured cellular grafting has become a prevalent and cost-effective method for treating stable vitiligo, with safety and effectiveness confirmed by two decades of studies. It critiques strict legislative oversight, suggesting it might unnecessarily increase costs and limit patient access.
Quickly fix tissue in formalin after excision to preserve it.
169 citations
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February 2018 in “Immunity” In this study, researchers found that quiescent stem cells resist immune attack due to downregulated antigen presentation, which may help explain the immune evasion of early cancer-initiating cells.
48 citations
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April 2008 in “Human Molecular Genetics” This study found that although progerin expression in mouse skin causes significant nuclear shape changes in keratinocytes, it does not result in alopecia or common skin abnormalities seen in human Hutchinson–Gilford progeria syndrome.