Injectable Macroporous Cryogels for Minimally Invasive Drug Delivery and Tissue Engineering
December 2025
in “
Journal of Pharma Insights and Research.
”
Studysummary This paper reviews the state of knowledge on injectable cryogels, highlighting their unique properties such as shape-memory and mechanical integrity, which allow for minimally invasive delivery via needles and potential applications in oncology and regenerative medicine. Our plain-language summary of this paper — not a Tressless recommendation.
Injectable macroporous cryogels, synthesized through cryogelation at sub-zero temperatures, offer unique properties such as shape-memory, mechanical robustness, and rapid swelling, allowing them to be delivered via minimally invasive procedures and regain their original form in situ. This paper discusses the fabrication principles, physicochemical characterization, and biomedical applications of these cryogels, highlighting their potential in fields like oncology and regenerative medicine. The cryotropic gelation mechanism, involving ice crystals as porogens, is crucial in defining the scaffold's microstructure.
