Improving the Stability of Retinol: Overcoming Obstacles Through Solid Lipid Particle Technology

    July 2025 in “ Journal of Investigative Dermatology ”
    P. Ludwig, Isabelle Bonnet, Ge Zhang, C. Thiel, Chun‐Chun Hsu, André Vincent
    TLDR Solid Lipid Particle technology makes retinol more stable, effective, and gentle on the skin.
    The study demonstrates that Solid Lipid Particle (SLP) technology significantly improves the stability, bioavailability, and skin tolerance of retinol in skincare. Over a 4-month real-life study, the SLP formulation retained 83% of retinol, compared to 46% with a market benchmark. It also increased collagen I by 43%, matching non-encapsulated retinol, and avoided irritation, as no IL-8 secretion was observed, unlike with non-encapsulated retinol, which increased IL-8 by 47%. This technology effectively overcomes retinol's traditional drawbacks, offering a stable and irritation-free anti-aging solution.
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