Co-Delivering Retinol And Niacinamide Via Liposomes: Enhanced Stability, Efficient Skin Permeation, And Improved Anti-Aging/Skin-Brightening Efficacy
August 2025
TLDR The new delivery system makes retinol and niacinamide more stable and effective for anti-aging and skin-brightening.
The study developed a liposomal co-delivery system (RN-Lip) to enhance the stability of retinol (RET) and improve the skin permeation of niacinamide (NA), addressing their individual limitations in skincare. The RN-Lip formulation showed a nanoscale structure with high loading capacity, effectively enhancing RET stability and skin retention of both ingredients. It promoted cellular uptake and protected cells from oxidative damage. The co-delivery system exhibited a synergistic effect in reducing melanin production and tyrosinase activity, and increased type I collagen expression, demonstrating superior anti-aging and skin-brightening efficacy compared to free ingredients. RN-Lip holds significant potential for advanced skincare applications.
