26 citations
,
April 2012 in “PubMed” In this study, myofibroblasts in rat cutaneous fibrosis were characterized by expressions of vimentin, α-SMA, and Thy-1, and may derive from pericytes or perifollicular dermal sheath cells.
26 citations
,
July 1992 in “International Journal of Dermatology” In this study, treating refractory alopecia universalis with low-dose cyclosporine A and prednisolone improved symptoms, with no recurring alopecia six months post-treatment and enhancements in immunologic function.
26 citations
,
January 1992 in “Cancer investigation” This study found that N-acetylcysteine effectively prevented cyclophosphamide-induced alopecia in rats, and ImuVert plus N-acetylcysteine prevented alopecia from a cyclophosphamide-cytarabine combination.
25 citations
,
October 2022 in “Ophthalmic Research” In this study, 650 nm low-level red light therapy may cause a short-term transient increase in retinal fovea perfusion density in children, with no lasting effects observed at 1 hour post-treatment.
25 citations
,
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that applying topical imiquimod during mid and late telogen in mice activates hair follicle stem cells and influences immune cell infiltration, promoting hair cycle entry independently of Wnt signaling.
25 citations
,
November 2005 in “PubMed” This study found that finasteride altered androgen receptor expression in the rat epididymis without affecting the morphology of epididymal epithelium, suggesting a change in hormonal status.
24 citations
,
August 2022 in “Immunity” This study found that control of Demodex mite colonization in mice required skin ILC2s and IL-13, highlighting their role in maintaining HF integrity and limiting mite overgrowth.
24 citations
,
September 2014 in “PloS one” This study demonstrated that thyroid hormone receptors play a crucial role in hair growth and skin health, as mice lacking these receptors showed impaired hair cycling and wound healing.
24 citations
,
January 2014 in “PubMed” This case report suggests that topical imiquimod cream may be an effective alternative treatment for generalized discoid lupus erythematosus without systemic involvement.
23 citations
,
December 2021 in “Frontiers in Immunology” This review discusses the significance of IL-1 family cytokines in skin inflammation and pathology, emphasizing their interactions with microbes and potential therapeutic applications, but reports no new clinical results.
23 citations
,
November 2020 in “Central-European Journal of Immunology/Central European Journal of Immunology” This review explores the autoimmune hypothesis of alopecia areata and the possible genetic and melanogenesis-associated autoantigens, but reports no new clinical findings.
23 citations
,
January 2010 in “Journal of Medical Primatology” This study found that alopecia in captive Rhesus macaques may be linked to chronic hypersensitivity dermatitis with CD4+ cell inflammation, possibly influenced by altered housing and reduced pathogen exposure.
23 citations
,
July 1997 in “British Journal of Dermatology” This study suggests that the inner root sheath plays a significant role in maintaining hair follicle homeostasis during the catagen phase's early stages.
23 citations
,
December 1995 in “Archives of Dermatology” This case report discusses a 32-year-old man's treatment for advanced androgenetic alopecia using a combination of topical minoxidil and oral finasteride, but no clinical outcomes are detailed.
22 citations
,
November 2024 in “Bioactive Materials” This study found that 3D-printed polyamine-modified hydrogels facilitate M2 macrophage polarization and exosome secretion, enhancing skin cell compatibility and promoting wound healing and hair follicle induction in an animal model through specific signaling pathways, suggesting potential for skin disorder therapies.
22 citations
,
December 2016 in “PloS one” In this study, researchers found that the EDMTFH protein is present in specific layers of the chicken embryo skin and feathers, suggesting its role in feather mechanics and development.
22 citations
,
February 2013 in “Wound Repair and Regeneration” In this study, CD109 overexpression in transgenic mice led to reduced inflammation and improved collagen organization during wound healing without affecting wound closure.
22 citations
,
June 2012 in “PLOS ONE” In this study, researchers found that impaired cholesterol biosynthesis in hair follicles may trigger an inflammatory immune response linked to primary cicatricial alopecia, providing new insights into the disorder's pathogenesis.
22 citations
,
March 1994 in “Journal of Heredity” In this study, researchers identified a mutation in mice that causes hair loss and immune system issues, located on chromosome 18.
21 citations
,
October 2011 in “PloS one” In this study, researchers identified three molecules in hair that varied with age, suggesting potential markers for aging and targets for cosmetic products.
21 citations
,
April 2010 in “Veterinary Dermatology” This study documented the progression of exfoliative cutaneous lupus erythematosus in German shorthaired pointers and found generally poor responses to therapies, including immunomodulatory drugs and a TNF-α inhibitor.
21 citations
,
January 2024 in “Science Immunology” This study developed a technique to limit genetic recombination to regulatory T cells to investigate whether self-tolerance is maintained in non-lymphoid tissues, an area previously not well understood.
21 citations
,
November 2021 in “Journal of the European Academy of Dermatology and Venereology” The French COVID-19 lockdown caused delays in diagnosing new melanoma cases, making them more severe.
21 citations
,
May 2019 in “Pediatrics in review” This review examines primary and secondary immunodeficiencies, focusing on how healthcare providers can recognize and manage these conditions in children; it reports no new clinical results.
21 citations
,
March 2019 in “Experimental Dermatology” This review discusses the role of perifollicular macrophages in hair growth and suggests targeting them could be relevant for managing hair growth disorders, but reports no new results.
21 citations
,
May 2014 in “Toxicological Sciences” This study found that skin exposure to toluene diisocyanate in mice creates immune-recognition reservoirs in the skin's stratum corneum and hair follicles, potentially leading to sensitization and allergic reactions.
21 citations
,
October 2011 in “British Journal of Dermatology” This study found that subcutaneous testosterone therapy improved scalp hair growth in a majority of androgen-deficient women who previously reported hair thinning and did not report hair loss as a side effect.
21 citations
,
August 2011 in “BMB Reports” This study successfully established an immortalized human dermal papilla cell line that maintains characteristics of original cells without malignant transformation, potentially benefiting hair research.
21 citations
,
June 2011 in “Investigative Ophthalmology & Visual Science” This article argues that human scalp hair follicles could serve as a surrogate model for studying immune privilege in the human eye, offering a novel approach for ocular IP research.
21 citations
,
July 2004 in “Apmis” This review describes the development of three mouse models using fluorescent proteins to visualize and study angiogenesis in tumors, particularly detailing interactions between tumor cells and the surrounding stroma.