TLDR Hydroxychloroquine showed some potential, but overall, the three drugs had limited success in treating lupus in dogs.
The study focused on Exfoliative Cutaneous Lupus Erythematosus (ECLE) in six German Shorthaired Pointer dogs, assessing the progression of the disease and the efficacy of three immunomodulatory drugs: ciclosporin, hydroxychloroquine, and adalimumab. Ciclosporin was administered to four dogs and showed some initial improvement, but lesions worsened over time. Hydroxychloroquine, given to three dogs, seemed to slow the disease's progression in two dogs and normalized globulin levels, while adalimumab, administered to two dogs, did not result in significant clinical improvement. The study concluded that the response to these therapies was generally poor, with hydroxychloroquine showing some promise for long-term treatment safety. The study also marked the first evaluation of a TNF-α inhibitor in canine lupus and documented the use of hydroxychloroquine in veterinary medicine.
144 citations,
September 2006 in “Clinics in Dermatology” Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.
38 citations,
August 2005 in “Veterinary dermatology” A disease causing skin issues in young adult German short-haired pointers is hereditary, with most affected dogs not responding to treatment.
84 citations,
March 2004 in “Veterinary Dermatology” Cyclosporin is effective in treating dog skin diseases and has fewer side effects compared to other treatments.
149 citations,
July 2002 in “Dermatologic clinics” Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.
May 2023 in “Journal of Clinical Medicine” New understanding and treatments for hair loss are improving, but more research is needed.
1 citations,
April 2010 in “Expert Review of Dermatology” The document concludes that early diagnosis and treatment are crucial for managing rare hair loss disorders and that more research is needed to improve treatment strategies.
February 2024 in “PloS one” Tofacitinib and adalimumab are promising treatments for cicatricial alopecia with few side effects.
1 citations,
January 2010 in “Elsevier eBooks” Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.
1 citations,
July 2019 in “British Journal of Dermatology” Minoxidil was more effective than laser therapy for hair loss, and the report also highlighted the need for more research on PRP for a different hair loss condition, the impact of social media on alopecia views, and a warning on turmeric causing nail discoloration.
