Cyclosporin A: A New Drug in the Field of Canine Dermatology

    March 2004 in “ Veterinary Dermatology
    E. Guaguere, Jean Steffan, Thierry Olivry
    Image of study
    TLDR Cyclosporin is effective in treating dog skin diseases and has fewer side effects compared to other treatments.
    In 2004, researchers found that cyclosporin, a drug with potent immunomodulating properties, was effective in treating canine skin diseases. The drug was found to block the transcription of cytokines genes in activated T lymphocytes and inhibit immune allergic reactions in mast cells, Langerhans cells, eosinophils, and keratinocytes. In randomized controlled trials, cyclosporin was as effective as glucocorticoids for treating canine atopic dermatitis at a dosage of 5 mg/kg. It also proved beneficial for treating perianal fistulas in dogs. The drug's pharmacokinetic properties were similar in dogs and humans, but its safety margin was much wider in dogs. Adverse reactions in dogs were mainly transient emesis and diarrhea during the first days of treatment, with other reactions like gingival hyperplasia, verruciform lesions, and hypertrichosis being dose-dependent and rare at therapeutic doses. Increased susceptibility to infections was not reported in dogs receiving this drug.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 17 results

      community RT1640 - Gray Hair Reversal Recipe

      in Research/Science  3 upvotes 2 years ago
      The conversation discusses a hair loss treatment formulation containing cyclosporin, minoxidil, and tacrolimus, and mentions ongoing research on hair color reversal. The treatment showed high efficacy in restoring hair color in trials with 40 to 50 people.

      community Forgotten 'Total Revival' Stack

      in Research/Science  42 upvotes 1 week ago
      Cyclosporine A is discussed as a powerful hair growth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.

      community how to compound topical cyclosporine

      in Treatment  9 upvotes 2 years ago
      The conversation is about compounding topical cyclosporine for hair loss, suggesting it needs an oil base like castor oil. The user seeks tips or tricks for the process.

      community Starting Way-316606 for the first time today.

      in Research/Science  30 upvotes 1 month ago
      A user is experimenting with a homemade solution of WAY-316606 for hair regrowth, combining it with other treatments like minoxidil and dutasteride. The community expresses concern over the safety and mental health implications of such drastic measures, with mixed opinions on the effectiveness of WAY-316606.

    Similar Research

    5 / 1000+ results