Successful Treatment of Generalized Discoid Lupus Erythematosus With Imiquimod Cream 5%: A Case Report and Review of the Literature

    January 2014 in “ PubMed
    Michael Park, Barbara Boone, Steven A. Devos
    Studysummary This case report suggests that topical imiquimod cream may be an effective alternative treatment for generalized discoid lupus erythematosus without systemic involvement.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    Discoid lupus erythematosus (DLE) is a chronic skin condition that can lead to scarring, hair loss, and pigmentary changes if not treated early. A case study of a 63-year-old man with generalized DLE, presenting with erythematous scaly patches on the face and other body parts, demonstrated successful treatment using imiquimod cream 5%. The cream was applied three times a week, every other week, resulting in almost complete recovery after 24 applications over two months. This case suggested that topical imiquimod could be an alternative treatment for generalized DLE.
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