January 2020 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study concluded that TrichoxidilTM positively affected hair growth by increasing growth factor expression and fibroblast proliferation, suggesting it may be a promising treatment for androgenetic alopecia.
January 2023 in “Pharmaceutics” In this study, researchers developed a new topical atraric acid formulation, AA-TF#15, which showed a significantly higher drug penetration and increased hair regrowth in mice compared to minoxidil and finasteride treatments, suggesting its potential effectiveness for treating scalp androgenic alopecia.
February 2022 in “Scientia Pharmaceutica” This study validated that six out of seven tested topical formulations for alopecia are compatible for 6-month use, suggesting they may be practical for compounding pharmacies.
March 2026 in “Journal of Cosmetic Dermatology” Topical Stemoxydine improves hair density in androgenetic alopecia with few side effects.
365 citations
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March 2021 in “Frontiers in Bioengineering and Biotechnology” This review discusses the potential of nanocarriers to enhance transdermal drug delivery and the combination of these carriers with physical methods, but it reports no new experimental results.
36 citations
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July 2017 in “Journal of controlled release” In this study, a new formulation of all-trans retinoic acid bound to polyvinyl alcohol showed reduced skin inflammation and sustained drug release for up to six days compared to free ATRA in vitro and in vivo.
20 citations
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May 2023 in “Cancer Nanotechnology” The researchers reported that their novel formulation of pterostilbene-loaded ethoniosomes with folic acid coating effectively targeted lung cancer cells in vitro and demonstrated promising results in animal models, indicating potential for future targeted chemotherapy applications.
19 citations
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May 2021 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses the progress in research on topical formulations for treating alopecia, highlighting potential advantages of advanced formulation technologies but reporting no new clinical results.
1 citations
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February 2024 in “Pharmaceutics” This review highlights recent developments in nanovesicular carriers for enhancing molecule delivery into and across the skin, focusing on the design and evolution of phospholipid and non-phospholipid systems used in cosmetics and treating various skin conditions.
1 citations
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April 2023 in “Biomolecules” This study found that hair care products containing fermented papaya, fermented mangosteen, and caffeine significantly inhibited hair loss, increased hair density and thickness, and improved hair follicle structure in individuals with androgenic or diffuse alopecia over three months compared to placebo and caffeine controls.
November 2025 in “Cosmetics” This study found that of the many ingredients advertised in shampoos as effective against hair loss, only caffeine, adenosine, placental proteins, and melatonin have limited clinical evidence supporting their efficacy, with most claimed active ingredients lacking any trial-based validation.
November 2025 in “International Journal of Molecular Sciences” This review highlights various treatments for androgenetic alopecia that target its underlying pathophysiological mechanisms, reporting enhanced hair growth, especially when combining drugs, which shows improved outcomes over individual drug use alone.
August 2025 in “Drug Design Development and Therapy” This review article examines current drugs for androgenetic alopecia, focusing on their mechanisms and clinical efficacy, noting that while finasteride and minoxidil are commonly approved treatments, new drugs targeting different pathogenic pathways have emerged, offering a broader understanding and reference for AGA treatment options.
March 2025 in “Carbohydrate Polymer Technologies and Applications” In this study, researchers developed a carboxylated β-cyclodextrin formulation to enhance finasteride's physicochemical properties, achieving an encapsulation efficiency of about 85% and indicating potential for controlled drug release in therapeutic applications. Their findings suggest this inclusion complex could improve delivery of hydrophobic drugs like finasteride.
August 2024 in “Cosmetics” This review highlights caffeine's diverse benefits in cosmetics and nutricosmetics, noting its antioxidant properties, ability to treat skin disorders like androgenic alopecia, and potential to enhance sunscreen effectiveness, though penetration into deeper skin layers remains challenging.
June 2024 in “American Journal of Biomedical Science & Research” This article discusses male androgenetic alopecia, describing its progression and pattern, and reports no new findings or clinical results.
January 2024 in “JOJ Dermatology & Cosmetics” This article discusses a trial evaluating patient satisfaction with the TH07 treatment for androgenetic alopecia but reports no clinical results.
July 2023 in “Journal of exploratory research in pharmacology” In this case report, a 47-year-old man with extensive psoriasis saw significant improvement in scaling and itching after using a new lotion containing clobetasol and other ingredients for one week, but further research is needed to confirm these findings.
This review highlights that nanotechnology offers promising avenues for enhancing drug delivery and developing new therapeutic strategies for androgenetic alopecia, though challenges remain in clinical translation and the need for long-term safety studies.
November 2025 in “Toxicology Communications” The study observed that topical minoxidil poses an increasing and potentially deadly risk to pets, particularly cats, highlighting the urgent need for better public education and product labeling.
39 citations
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August 2022 in “Pharmaceutics” This study found that the combination of letrozole and quercetin loaded in spanlastics showed enhanced cytotoxicity and other anticancer effects against MCF-7 breast cancer cells compared to individual treatments.
119 citations
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June 2021 in “Heliyon” This review examines the phytochemical constituents and pharmacological effects of licorice, discussing its potential health benefits and side effects without reporting new clinical results.
37 citations
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November 2024 in “Cosmetics” This review examines the promising role of nanocarriers, specifically liposomes and ethosomes, in enhancing transdermal drug delivery for skin diseases. Ethosomes, highlighted for their ability to penetrate deeper skin layers, show potential for more effective treatments but require further clinical investigation.
32 citations
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June 2024 in “Pharmaceutics” This review explores the use of topical and transdermal delivery for drugs and cosmetics, highlighting the benefits of avoiding side effects and rapid metabolism, with a focus on nanoparticulate formulations and techniques for studying skin penetration.
25 citations
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August 2015 in “Molecules” This study found that mimosine dipeptide enantiomers inhibit melanogenesis and cyclooxygenase enzymes in B16F10 melanoma cells, suggesting potential for treating skin hyperpigmentation and inflammation.
24 citations
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March 2024 in “Antioxidants” In this review, researchers reported that cinnamon and ginger supplementation may benefit PCOS patients by improving hormonal status, lipid profiles, obesity, and insulin resistance through oxidative stress and inflammation reduction.
21 citations
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February 2023 in “Pharmaceuticals” This study reports that extracts from pomegranate leaves contain bioactive compounds with antioxidant, antimicrobial, and skin-beneficial properties, suggesting their potential use in nutraceutical and cosmeceutical applications.
19 citations
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March 2023 in “Resources” This review discusses the potential of solid-state fermentation for extracting polyphenolic compounds from agro-industrial wastes, but it reports no new experimental results.
18 citations
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January 2022 in “Nutrients” This review discusses potential agents, including acetyl-L-carnitine and vitamins, for repurposing in managing chemotherapy-induced peripheral neuropathy and reports no clinical results; the authors emphasize the need for further research.
17 citations
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August 2023 in “Frontiers in Pharmacology” This review highlights the potential of Asteraceae plants as antidiabetic agents and their beneficial effects on conditions such as cardiovascular disease and liver cirrhosis, suggesting their use as food and nutraceuticals could help manage diabetes.