40 citations
,
July 2013 in “Skin Pharmacology and Physiology” This study reports that among men, skin surface hydration and pH change with age, but transepidermal water loss and sebum production show less variation.
260 citations
,
January 2019 in “Pharmaceutics” This study highlights that niosomes, or non-ionic surfactant based vesicles, offer an advantageous drug delivery system due to their stability, cost-effectiveness, and ability to enhance drug bioavailability and targeting efficiency for various therapeutic agents.
52 citations
,
December 2000 in “Archives of Dermatological Research” This study found that the stratum corneum of scalp skin in humans has distinct functional characteristics compared to the facial skin and volar forearm, including higher hydration levels and intermediate epidermal turnover rates.
2 citations
,
November 2024 in “International Journal of Pharmaceutics X” In this study, desmopressin-loaded elastic liposomes (ODEL1) showed improved permeation and drug deposition across rat skin by altering the skin's cohesive energies and causing reversible changes on its surface.
3 citations
,
August 2020 in “Nutrition Journal” This study found that spinach-derived thylakoid supplementation, combined with a calorie-restricted diet, led to more significant improvements in weight loss and insulin sensitivity in obese women with PCOS than calorie restriction alone.
1 citations
,
October 2023 in “Animals” This study found that supplementing raccoon dogs' diets with 0.25 g/kg Platycladus orientalis leaf extract improved growth performance and altered intestinal microbiota, but higher doses may have adverse effects.
This review reports that oral collagen peptide supplements may improve skin elasticity, hydration, and wrinkle appearance while also supporting hair and nail health and wound healing, but emphasizes the need for longer, high-quality studies due to current research limitations and variability in findings.
14 citations
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May 2023 in “Dermatologic Surgery” VYC-12L effectively improves skin smoothness, reduces fine lines, and boosts hydration.
5 citations
,
November 2025 in “Biomolecules” This review examines the benefits of topical hyaluronic acid in cosmetic applications, noting its ability to penetrate the skin in low-molecular-weight forms and highlighting safety supported by clinical trials.
5 citations
,
July 2022 in “Frontiers in Medicine” In this study, the combination of ECM-C with microneedle and radiofrequency treatments improved periorbital wrinkles, skin elasticity, and thickness more effectively than ECM-C with microneedles alone, but subjective evaluations showed no significant differences.
2 citations
,
June 2023 in “Journal of clinical medicine” This review found that both oral and topical soy-based products showed positive effects on various skin-related outcomes, including aging signs and skin barrier function, but topical applications were more likely to improve skin barrier status compared to oral supplementation.
1 citations
,
May 2021 in “Research journal of topical and cosmetic sciences” This study observed that taking 500mg/day of Microcore’s Muttaijow ComplexTM for 12 weeks significantly improved the appearance of skin, hair, and nails in healthy middle-aged adults.
April 2026 in “Diagnostics” This study found that skin changes in morbidly obese individuals are associated with underlying metabolic disturbances but are not currently valuable as independent tools for assessing metabolic risk or treatment response.
November 2024 in “International Journal of Research in Dermatology” SesZen-BioTM improves skin health and reduces signs of aging.
This article explores the potential applications of polyglutamic acid in cosmetics, discussing its benefits for skincare and haircare, but reports no new experimental results.
May 2021 in “Research journal of topical and cosmetic sciences” In this study, oral supplementation of Microcore’s TrichovitalsTM significantly improved the appearance of facial skin, hair, and nails over 12 weeks in healthy middle-aged adults compared to a control group.
December 2025 in “Journal of Cosmetic Dermatology” The new treatment improved keratosis pilaris symptoms and mood in 28 days.
4 citations
,
August 2025 in “Journal of Cosmetic Dermatology” This study found that while hormone replacement therapy can improve skin aging in menopausal women, inconsistent findings and a lack of robust clinical trials mean it isn't recommended purely for skin benefits.
In this clinical trial, the researchers observed that a biotin and silica supplement reduced hair fall, increased hair growth rate, and improved skin elasticity, hydration, and nail quality over 90 days without adverse effects.
298 citations
,
June 2019 in “Marine Drugs” This review discusses the properties and bioextraction methods of chitin and chitosans, emphasizing their potential use in eco-friendly cosmetic manufacturing and reports no new experimental findings.
48 citations
,
May 2021 in “Molecules” The researchers found that plant extracts from Papaver rhoeas L., Clitoria ternatea L., and Carthamus tinctorius L. are effective natural cosmetic dyes, offering intense and stable colors without cytotoxicity.
44 citations
,
October 2019 in “International Journal of Molecular Sciences” This article reviews various studies and suggests that melatonin, produced both naturally in the skin and applied topically, may offer significant protection against environmental damage, making it a promising candidate for skincare therapies.
26 citations
,
October 2021 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses the potential benefits and biological activities of MSC secretome for various skin applications, but it reports no new clinical results.
8 citations
,
August 2012 in “Clinical, cosmetic and investigational dermatology” In this study, Doublebase gel was more effective in maintaining and increasing skin hydration compared to Aqueous cream BP, with higher patient satisfaction and preference for future use.
5 citations
,
October 2022 in “Cosmetics” This article reviews in-vitro and cell-free methods for assessing the efficacy of herbal ingredients in cosmetic formulations for skin health and hair growth, but it reports no new clinical results.
4 citations
,
November 2023 in “Journal of Cosmetic Dermatology” In this study, researchers found that negative pressure fractional microneedle radiofrequency significantly improved periorbital wrinkles, hydration, and dermal thickness in patients with periorbital aging, while also increasing orderly collagen and elastic fibers, with minimal adverse effects reported.
4 citations
,
January 2023 in “Veterinary Sciences” This study found that applications of a shampoo and mousse containing plant extracts improved coat quality in dogs with a chronic keratinisation disorder without affecting skin hydration or hair lipids over the study period.
3 citations
,
September 2023 in “Cosmetics” This study found that training in a hypoxic chamber did not significantly impact skin features in overweight and obese women, though it did result in a notable reduction in body weight and BMI.
1 citations
,
October 2025 in “Beni-Suef University Journal of Basic and Applied Sciences” This study reviews lipid-based nanocosmeceuticals and reports that they enhance therapeutic effectiveness in dermatological applications by improving skin hydration, reducing wrinkles, and effectively managing conditions like psoriasis and eczema, though further large-scale trials and regulatory alignment are needed for clinical use.
May 2026 in “Applied Sciences” In this review, the authors reported that sprout extracts, rich in bioactive compounds, show promising effects on skin health, such as enhancing collagen synthesis, improving hydration, and reducing inflammation, though most evidence comes from laboratory and animal studies.