A Randomized, Multicenter, Evaluator-Blind Study to Evaluate the Safety and Effectiveness of VYC-12L Treatment for Skin Quality Improvements

    May 2023 in “ Dermatologic Surgery ”
    Macrene Alexiades, Melanie D. Palm, Joely Kaufman‐Janette, Ira D. Papel, Sarah J. Cross, Steve Abrams, Smita Chawla
    TLDR VYC-12L effectively improves skin smoothness, reduces fine lines, and boosts hydration.
    The study assessed the safety and effectiveness of VYC-12L, a hyaluronic acid filler, for skin quality improvement in 209 participants across 14 US sites. The VYC-12L group showed significant improvements in skin smoothness and fine lines, with responder rates of 57.9% and 58.3% at month 1, compared to 4.5% and 5.4% in the delayed treatment control group. These benefits were maintained through month 6, and skin hydration also increased significantly. Injection site reactions were common but mostly mild or moderate, resolving within 7 days. The study concluded that VYC-12L is effective and safe for enhancing skin quality, though it noted the need for more diverse participant representation in future research.
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