Prospective Clinical Evaluation of Cross-Linked Hyaluronic Acid Dermal Filler (30 mg) for Facial Rejuvenation
October 2025
in “
Plastic & Reconstructive Surgery Global Open
”
Studysummary This study found that a novel cross-linked hyaluronic acid dermal filler is safe and effective for improving lip enhancement, cheekbone augmentation, and nasolabial folds across different skin types, with significant improvements in wrinkle severity and overall facial aesthetics observed.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study evaluated the safety and efficacy of a 30 mg cross-linked hyaluronic acid dermal filler for facial rejuvenation in 122 participants, primarily with Fitzpatrick skin types 3 and 4. Over a 1-year follow-up, significant improvements were observed in wrinkles, facial aesthetics, cheekbones, and lips, with no filler-related adverse events. The filler effectively reduced wrinkle depth, increased cheek volume, and improved lip contour, with 36.88% of patients being "very much improved" after 1 year. The study highlights the filler as a safe, minimally invasive alternative to surgical procedures, though it notes limitations such as the lack of a control group and a predominantly Fitzpatrick skin type 3 and 4 population, which may affect generalizability. Future studies are recommended to include a more diverse population and control groups.
