Ultra-High-Frequency Ultrasound as an Innovative Imaging Evaluation of Hyaluronic Acid Filler in Nasolabial Folds

    August 2023 in “ Diagnostics ”
    Giorgia Salvia, Nicola Zerbinati, Flavia Manzo Margiotta, Alessandra Michelucci, Giammarco Granieri, Cristian Fidanzi, Riccardo Morganti, Marco Romanelli, Valentina Dini
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    Studysummary This study observed that using ultra-high-frequency ultrasound with 70 MHz probes effectively assessed the distribution of hyaluronic acid fillers and improvements in nasolabial fold wrinkles, with significant changes in dermal thickness and wrinkle scores maintained 24 weeks after treatment. Our plain-language summary of this paper — not a Tressless recommendation.
    The study involved 13 patients who received hyaluronic acid (HA) filler for nasolabial fold correction, evaluated using ultra-high-frequency ultrasound (UHFUS). The UHFUS showed an increase in dermal thickness by 11% immediately after injection, and by 7.4% and 6.8% for the right and left side, respectively, after 24 weeks. Wrinkle severity reduced by 56% immediately after the injection and by 47.1% at 6 months. The study concluded that UHFUS is a valuable tool in aesthetic medicine for evaluating the distribution and permanence of HA fillers. However, the study acknowledges limitations including a relatively small sample size and the need for further research involving larger and more diverse populations.
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