research Primary Cicatricial Alopecia: Recent Advances in Understanding and Management
New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.
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research New Substrates for Stem Cell Control
New materials help control stem cell growth and specialization for medical applications.
research New Fluorogenic Probes for Neutral and Alkaline Ceramidases
New probes were created to effectively measure specific enzymes involved in fat metabolism, which could help develop new drugs.
research High-Content Drug Screening for Rare Diseases
High-content screening is useful for finding new treatments for rare diseases and has led to FDA-approved drugs.
research A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels
The conclusion is that a new test was created to find substances that affect specific ion channels, and it works well for drug discovery.
research Drug Repositioning: Current Approaches and Their Implications in the Precision Medicine Era
Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.
research Logic-Based Modeling and Drug Repurposing for the Prediction of Novel Therapeutic Targets and Combination Regimens Against E2F1-Driven Melanoma Progression
Tadalafil and Finasteride may help treat aggressive melanoma.
research Improved Forensic Hair Evidence for Drugs of Abuse by Mass Spectrometry
Forensic hair analysis for drugs is now more reliable and accurate.
research What Should It Take to Describe a Substance or Product as 'Sperm-Safe'?
Products should be called 'sperm-safe' only after thorough, well-designed tests.
research Therapeutics for COVID-19 and Post COVID-19 Complications: An Update
New treatments for COVID-19 show promise, but more effective antiviral drugs are needed.
research Pre-Clinical In-Vitro Assays for High Throughput Screening of Drug Candidates for Protection and Restoration of Immune Privilege in Alopecia Areata
The research developed methods to test drugs that could protect and restore hair follicle protection in a hair loss condition.
research Role of Drug Repurposing in Sustainable Drug Discovery
Drug repurposing speeds up drug development, saves money, and has led to about a third of new drug approvals.
research Discovering Hair Loss Treatments That Increase The Wnt/Beta-Catenin Signaling Pathway By High-Throughput Screening
Aminoacridine and Abemaciclib, especially combined with Minoxidil, show promise for treating hair loss.
research Establishment of Type II 5α-Reductase Over-Expressing Cell Line as an Inhibitor Screening Model
A reliable model for screening type II 5α-reductase inhibitors was created and validated.
research Small Molecules and Small Molecule Drugs in Regenerative Medicine
Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.
research Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels
Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.
research Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives
Bioactive molecules show promise for improving skin repair and regeneration by overcoming current challenges with further research.
research A New Label-Free Screen for Steroid 5α-Reductase Inhibitors Using LC-MS
Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.
research Data-Driven Analysis to Understand Long COVID Using Electronic Health Records From the RECOVER Initiative
Long COVID patients have more health issues than non-infected people.
research The Development of an In Vitro Human Hair Follicle Organoid With a Complexity Similar to That In Vivo
Scientists created a lab-grown hair follicle model that behaves like real hair and could improve hair loss treatment research.
research Saccharomyces Cerevisiae BLYAS, A New Bioluminescent Bioreporter For Detection Of Androgenic Compounds
The engineered yeast strain BLYAS can quickly and sensitively detect androgenic chemicals.
research Development of a Novel In Vitro Strategy to Understand the Impact of Shaving on Skin Health: Combining Tape Strip Exfoliation and Human Skin Equivalent Technology
The method effectively mimics shaving damage on skin for testing skincare products.
research High-Throughput and Direct Measurement of Androgen Levels Using Turbulent Flow Chromatography Liquid Chromatography-Triple Quadrupole Mass Spectrometry to Discover Chemicals That Modulate Dihydrotestosterone Production in Human Prostate Cancer Cells
Researchers found four natural compounds that can change DHT levels in prostate cancer cells.
research Scalable and High-Throughput Production of an Injectable Platelet-Rich Plasma (PRP)/Cell-Laden Microcarrier/Hydrogel Composite System for Hair Follicle Tissue Engineering
The developed system could effectively treat hair loss and promote hair growth.
research Screening of Synthetic and Natural Product Databases: Identification of Novel Androgens and Antiandrogens
Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.
research Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for Screening Steroid 5-Alpha Reductase in Human and Fish Cell Lines
A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.
research The Role of 3Rs in the Age of One Health: Where We Are and Where We’re Going
Innovative methods are reducing animal testing and improving biomedical research.
research Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing
Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.
research Technology Transfer And The Climate Of Change
The document concludes that a Quality Management System is crucial for maintaining product quality through innovation and proper technology transfer in the pharmaceutical industry.
research Past and Future Strategies for GPCR Deorphanization
Finding functions for unknown GPCRs is hard but key for making new drugs.