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In this study, researchers used a new method with platelet-rich plasma-loaded microcarriers to enhance dermal papilla cell activity and hair follicle regeneration, achieving significant hair and vessel growth in a mouse model compared to control groups.

This study developed methods for detecting carboxy-finasteride in urine for doping control, demonstrating detection up to 49 hours post-administration with high precision and accuracy.

This study developed a 3D ovarian cancer model using microtumours, which effectively mimics minimal residual disease and supports the identification of new drug targets like perhexiline for treatment-resistant cells.

This thesis explores how optical coherence tomography and advanced imaging methods may address clinical needs in fields like interventional pulmonology and dermatology, highlighting their potential for disease assessment and staging.

This study identified 30 new compounds with significant androgen receptor binding affinity through a combination of virtual screening and in vitro testing.

In this study, researchers developed a sensitive assay to measure the inhibition of steroid 5-α reductase (5AR) by chemicals like finasteride and dutasteride, revealing species-specific differences in inhibitor efficacy between human and fish cell lines.

This study developed a new human in vitro hair model that replicates in vivo hair characteristics and may be suitable for high throughput screening of hair growth treatments.

This study found that four microRNAs, which were significantly upregulated in balding hair follicle papilla cells, could play a role in the development of male pattern baldness.

This study introduces a novel in vitro model for clubfoot fibrosis to enable high-throughput drug screening and found that while the model increased collagen deposition, the antifibrotic drug minoxidil effectively inhibited the expression of collagen cross-linking enzymes.

This study introduces a spherical skin model that effectively mimics key features of human skin, offering a scalable and rapid alternative for non-animal dermatological and cosmetic testing.

This review discusses recent advances in droplet microfluidics for chip-based technologies such as single-cell analysis, small-scale cell cultures, and high-throughput drug screening, and it reports no new results.

This study engineered a bioluminescent yeast strain responsive to androgenic chemicals, demonstrating rapid and sensitive detection suitable for high-throughput screening and environmental monitoring.

This study developed a reliable and convenient cell-based model to screen for type II 5α-reductase inhibitors, identifying Curcumae longae and Mori ramulus extracts as potential candidates.

This study developed thermo-reversible glycol chitosan hydrogels that effectively form and maintain 3D cell spheroids within one day, offering a simplified method for creating biologically realistic cultures for tissue regeneration and drug screening applications.

This study developed a method using ultra-performance liquid chromatography and mass spectrometry to detect illegal substances in hair loss prevention cosmetics, revealing that some products contained high levels of minoxidil and finasteride, posing safety risks.

In this study, researchers developed a microfluidics-based method for creating uniform, size-controlled stem cell spheroids that enhance osteogenic differentiation when encapsulated in alginate-RGD microgels.

This study demonstrated that using finasteride impurity as a non-isotopically labeled internal standard in paper spray ionization–mass spectrometry can effectively and efficiently measure finasteride tablet dissolution, achieving results comparable to high-performance liquid chromatography.

This review highlights the need for improved methods in cosmetic safety assessment, emphasizing the potential of engineered skin tissue for more effective detection and toxicological evaluation of cosmetic products, compared to traditional methods.

This study found that rhamnose can restore hair-inducing gene expression in dermal papilla cells and accelerate hair follicle regeneration by promoting the hair cycle into the anagen phase, suggesting its potential therapeutic application for alopecia treatment.

This review discusses the American Society of Preventive Oncology's focus on cancer prevention and highlights the ongoing challenges and developments in screening, tobacco control, and the need for innovative risk-reduction strategies; it reports no new research findings.

The document concludes that a Quality Management System is crucial for maintaining product quality through innovation and proper technology transfer in the pharmaceutical industry.

This study developed and validated a label-free assay using LC-MS to screen for S5αR inhibitors, identifying Thai herbal extracts, Impatiens balsamina L. and Curcuma longa L., as promising sources.

This review discusses advanced techniques for investigating stem cell fate at the single-cell level, including lineage tracing, time-lapse imaging, and molecular profiling, but reports no new research results.

This review explores recent advancements in precise cell manipulation technologies, detailing the status, principles, benefits, limitations, and future potential of methods like single-cell manipulation and 3D bioprinting for cells and tissue engineering.

This review summarizes recent research and patents on 17β-HSD3, 17β-HSD5, and 3α-HSD3 inhibitors, suggesting their potential in treating androgen-dependent diseases, but reports no new clinical results.

In this study, researchers used EHR data from two large PCORnet networks to identify a range of long COVID diagnoses, highlighting varying post-acute risks across populations in NYC and Florida.

This systematic review synthesizes the current state of drug repurposing, revealing its potential in various therapeutic areas like oncology and infectious diseases through insights from mechanistic studies and real-world evidence, and discusses emerging tools and challenges in the field.

This study found that human dermal fibroblasts can promote the viability and proliferation of microvascular endothelial cells in vitro, revealing important interactions at play in hair growth.

This study found that the peptides RMYYY and VMYMI displayed stronger binding energy and more frequent interactions with HPGDS compared to the native inhibitor, suggesting potential as future therapeutic drugs.

In this in-vitro study, researchers identified finasteride as the most effective FDA-approved drug for expanding functional myeloid-derived suppressor cells, suggesting its potential future use in immunosuppressive therapies.