Quantitative Analysis of Finasteride Tablets Dissolution Content with Non-Isotopically Labeled Internal Standard by Paper Spray Ionization Mass Spectrometry

    September 2018 in “ Journal of Separation Science ”
    Yang Liu, Yanan Zhou, Yandong Dai, Zhuang Zhao, Lan He, Qingsheng Zhang
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    Studysummary This study demonstrated that using finasteride impurity as a non-isotopically labeled internal standard in paper spray ionization–mass spectrometry can effectively and efficiently measure finasteride tablet dissolution, achieving results comparable to high-performance liquid chromatography. Our plain-language summary of this paper — not a Tressless recommendation.
    This paper discusses the use of paper spray ionization mass spectrometry (PSI-MS) with a non-isotopically labeled internal standard for the quantitative analysis of finasteride tablets dissolution content. The study found that PSI-MS is a promising method for the rapid screening of finasteride due to its easy-to-use and testing speed. The method uses a non-isotopically labeled internal standard and is able to accurately measure the amount of finasteride and its impurities in the tablets. The use of methanol/water solvent and longer drying times improved the sensitivity and accuracy of the method. This method could be useful for quality control and pharmacokinetic studies of finasteride tablets.
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